Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones

Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can open the local chromatin. However, a gap...

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Veröffentlicht in:	Nature genetics 2020-04, Vol.52 (4), p.418-427
Hauptverfasser:	Iwafuchi, Makiko, Cuesta, Isabel, Donahue, Greg, Takenaka, Naomi, Osipovich, Anna B., Magnuson, Mark A., Roder, Heinrich, Seeholzer, Steven H., Santisteban, Pilar, Zaret, Kenneth S.
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/35 38/39 38/91 45 631/136 631/208 631/337 631/532 64 64/60 82 82/80 Agriculture Amino Acid Sequence Amino acids Animal Genetics and Genomics Animals Arrays Binding sites Biomedical and Life Sciences Biomedicine Cancer Research Cell Line Chromatin Chromatin - genetics Deoxyribonucleic acid DNA DNA - genetics Embryonic development Embryos Female Gene Expression Regulation, Developmental - genetics Gene Function Gene Regulatory Networks - genetics Genetic algorithms Genetic aspects Histones Histones - genetics Human Genetics Humans Mice Mice, Inbred C57BL Molecular interactions Mutation Nucleosomes - genetics Peptides Physiological aspects Proteins Transcription factors Transcription Factors - genetics Transcription, Genetic - genetics
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