Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones
Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can open the local chromatin. However, a gap...
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| Veröffentlicht in: | Nature genetics 2020-04, Vol.52 (4), p.418-427 |
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| creator | Iwafuchi, Makiko Cuesta, Isabel Donahue, Greg Takenaka, Naomi Osipovich, Anna B. Magnuson, Mark A. Roder, Heinrich Seeholzer, Steven H. Santisteban, Pilar Zaret, Kenneth S. |
| description | Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can open the local chromatin. However, a gap has remained in understanding how molecular interactions with the nucleosome contribute to the chromatin-opening phenomenon. Here we identified a short α-helical region, conserved among FOXA pioneer factors, that interacts with core histones and contributes to chromatin opening in vitro. The same domain is involved in chromatin opening in early mouse embryos for normal development. Thus, local opening of chromatin by interactions between pioneer factors and core histones promotes genetic programming.
An α-helical region conserved among FOXA pioneer factors interacts with core histones and promotes chromatin opening in vitro. This region also promotes chromatin opening in early mouse embryos and is required for normal development. |
| doi_str_mv | 10.1038/s41588-020-0591-8 |
| format | Article |
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An α-helical region conserved among FOXA pioneer factors interacts with core histones and promotes chromatin opening in vitro. This region also promotes chromatin opening in early mouse embryos and is required for normal development.</description><subject>38</subject><subject>38/35</subject><subject>38/39</subject><subject>38/91</subject><subject>45</subject><subject>631/136</subject><subject>631/208</subject><subject>631/337</subject><subject>631/532</subject><subject>64</subject><subject>64/60</subject><subject>82</subject><subject>82/80</subject><subject>Agriculture</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Arrays</subject><subject>Binding sites</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Line</subject><subject>Chromatin</subject><subject>Chromatin - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Embryonic development</subject><subject>Embryos</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwafuchi, Makiko</au><au>Cuesta, Isabel</au><au>Donahue, Greg</au><au>Takenaka, Naomi</au><au>Osipovich, Anna B.</au><au>Magnuson, Mark A.</au><au>Roder, Heinrich</au><au>Seeholzer, Steven H.</au><au>Santisteban, Pilar</au><au>Zaret, Kenneth S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>52</volume><issue>4</issue><spage>418</spage><epage>427</epage><pages>418-427</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><abstract>Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can open the local chromatin. However, a gap has remained in understanding how molecular interactions with the nucleosome contribute to the chromatin-opening phenomenon. Here we identified a short α-helical region, conserved among FOXA pioneer factors, that interacts with core histones and contributes to chromatin opening in vitro. The same domain is involved in chromatin opening in early mouse embryos for normal development. Thus, local opening of chromatin by interactions between pioneer factors and core histones promotes genetic programming.
An α-helical region conserved among FOXA pioneer factors interacts with core histones and promotes chromatin opening in vitro. This region also promotes chromatin opening in early mouse embryos and is required for normal development.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>32203463</pmid><doi>10.1038/s41588-020-0591-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1291-6246</orcidid><orcidid>https://orcid.org/0000-0001-8932-3145</orcidid><orcidid>https://orcid.org/0000-0003-1860-2491</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 38 38/35 38/39 38/91 45 631/136 631/208 631/337 631/532 64 64/60 82 82/80 Agriculture Amino Acid Sequence Amino acids Animal Genetics and Genomics Animals Arrays Binding sites Biomedical and Life Sciences Biomedicine Cancer Research Cell Line Chromatin Chromatin - genetics Deoxyribonucleic acid DNA DNA - genetics Embryonic development Embryos Female Gene Expression Regulation, Developmental - genetics Gene Function Gene Regulatory Networks - genetics Genetic algorithms Genetic aspects Histones Histones - genetics Human Genetics Humans Mice Mice, Inbred C57BL Molecular interactions Mutation Nucleosomes - genetics Peptides Physiological aspects Proteins Transcription factors Transcription Factors - genetics Transcription, Genetic - genetics |
| title | Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones |
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