Ex vivo Ikkβ ablation rescues the immunopotency of mesenchymal stromal cells from diabetics with advanced atherosclerosis

Abstract Aims Diabetes is a conventional risk factor for atherosclerotic cardiovascular disease and myocardial infarction (MI) is the most common cause of death among these patients. Mesenchymal stromal cells (MSCs) in patients with type 2 diabetes mellitus (T2DM) and atherosclerosis have impaired a...

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Veröffentlicht in:	Cardiovascular research 2021-02, Vol.117 (3), p.756-766
Hauptverfasser:	Kizilay Mancini, Ozge, Huynh, David N, Menard, Liliane, Shum-Tim, Dominique, Ong, Huy, Marleau, Sylvie, Colmegna, Ines, Servant, Marc J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - immunology Case-Control Studies Cell Proliferation Cells, Cultured Cellular Senescence Coculture Techniques Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - immunology Disease Models, Animal Editor's Choice Female Humans I-kappa B Kinase - antagonists & inhibitors I-kappa B Kinase - genetics I-kappa B Kinase - metabolism Inflammation Mediators - metabolism Lymphocyte Activation Male Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - enzymology Mesenchymal Stem Cells - immunology Mice Mice, Inbred C57BL Middle Aged Myocardial Infarction - enzymology Myocardial Infarction - immunology Myocardial Infarction - surgery Original Phenotype Protein Kinase Inhibitors - pharmacology Secretome Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism
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