Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition

Alveologenesis is a developmental step involving the expansion of the lung surface area which is essential for gas exchange. The gas exchange process is mediated by alveolar type I (AT1) cells, which are known to be differentiated from alveolar type II (AT2) or bipotent cells. Due to the difficulty...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2021-02, Vol.39 (2), p.156-169
Hauptverfasser:	Kanagaki, Shuhei, Ikeo, Satoshi, Suezawa, Takahiro, Yamamoto, Yuki, Seki, Masahide, Hirai, Toyohiro, Hagiwara, Masatoshi, Suzuki, Yutaka, Gotoh, Shimpei
Format:	Artikel
Sprache:	eng
Schlagworte:	alveolar epithelial cells Alveoli Cell differentiation Differentiation (biology) Embryonic Stem Cells/Induced Pluripotent Stem Cells Epithelial cells Fetuses Fibroblasts Gas exchange Gene sequencing lung Lungs Organoids Pluripotency pluripotent stem cells Ribonucleic acid RNA Signaling single‐cell analysis Stem cells Wnt protein Wnt signaling pathway
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