(−)‐Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy

Introduction We conducted an open‐label study to examine the effects of the flavonoid (−)‐epicatechin in seven ambulatory adult patients with Becker muscular dystrophy (BMD). Methods Seven participants received (−)‐epicatechin 50 mg twice per day for 8 weeks. Pre‐ and postprocedures included biceps...

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Veröffentlicht in:	Muscle & nerve 2021-02, Vol.63 (2), p.239-249
Hauptverfasser:	McDonald, Craig M., Ramirez‐Sanchez, Israel, Oskarsson, Björn, Joyce, Nanette, Aguilar, Candace, Nicorici, Alina, Dayan, Jonathan, Goude, Erica, Abresch, R. Ted, Villarreal, Francisco, Ceballos, Guillermo, Perkins, Guy, Dugar, Sundeep, Schreiner, George, Henricson, Erik K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine kinase Adenosine monophosphate Adult aerobic exercise, Becker muscular dystrophy, epicatechin, mitochondrial biogenesis follistatin AMP Becker's muscular dystrophy Bioenergetics Biomarkers Biopsy Biosynthesis Blotting, Western Catechin - therapeutic use Clinical Clinical s Creatine Creatine kinase Creatine Kinase - metabolism Cristae Dysferlin - metabolism Dystrophy Electron microscopy Epicatechin Exercise Test Flavonoids Follistatin Follistatin - metabolism Heart Rate Hepatocytes Humans Kinases Lactic acid Lactic Acid - blood Male MEF2 Transcription Factors - metabolism Microscopy, Electron Middle Aged Mitochondria Mitochondria - ultrastructure Mitochondrial Proteins - metabolism Mitochondrial Size Muscle Proteins - metabolism Muscle Strength Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Muscle, Skeletal - ultrastructure Muscular dystrophy Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - metabolism Muscular Dystrophy, Duchenne - pathology Muscular Dystrophy, Duchenne - physiopathology Myoblasts Myocytes MyoD Protein - metabolism Myogenic Regulatory Factor 5 - metabolism Myogenin Myogenin - metabolism Myostatin Myostatin - metabolism Organelle Biogenesis Oxygen Consumption Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Physical training Protein kinase Proteins Regeneration Saturation index Skeletal muscle Transcription Utrophin - metabolism Volume measurement Western blotting
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