Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish

Rapid wound detection by distant leukocytes is essential for antimicrobial defence and post-infection survival 1 . The reactive oxygen species hydrogen peroxide and the polyunsaturated fatty acid arachidonic acid are among the earliest known mediators of this process 2 – 4 . It is unknown whether or...

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Veröffentlicht in:	Nature cell biology 2020-09, Vol.22 (9), p.1049-1055
Hauptverfasser:	Katikaneni, Anushka, Jelcic, Mark, Gerlach, Gary F., Ma, Yanan, Overholtzer, Michael, Niethammer, Philipp
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/10 14/63 45/70 631/80 631/80/84/1372 64/116 96/35 96/95 Animals Antiinfectives and antibacterials Arachidonate 5-lipoxygenase Arachidonate 5-Lipoxygenase - metabolism Arachidonic acid Arachidonic Acid - metabolism Biocompatibility Biomedical and Life Sciences Biosensors Cancer Research Cell Biology Cell death Chemotaxis Danio rerio Developmental Biology Fatty acids Fins Hydrogen peroxide Immune system Letter Leukocytes Leukocytes - metabolism Life Sciences Lipid peroxidation Lipid Peroxidation - physiology Lipids Lipoxygenase Observations Oxidases Oxidation-Reduction Perfusion Peroxidation Polyunsaturated fatty acids Properties Reactive oxygen species Reactive Oxygen Species - metabolism Stem Cells Wave propagation Wound healing Wounds Wounds and Injuries - metabolism Zebrafish Zebrafish - metabolism
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