Nicotinic receptor pharmacology in silico: Insights and challenges

Nicotinic acetylcholine receptors (nAChR) are homo- or hetero-pentameric ligand-gated ion channels of the Cys-loop superfamily and play important roles in the nervous system and muscles. Studies on nAChR benefit from in silico modeling due to the lack of high-resolution structures for most receptor...

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Veröffentlicht in:	Neuropharmacology 2020-10, Vol.177, p.108257-108257, Article 108257
1. Verfasser:	Gulsevin, Alican
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric activation Computational modeling Ligand-gated ion channel Nicotinic acetylcholine receptor Structure modeling α7 nAChR
Online-Zugang:	Volltext
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