Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome

Abstract Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular processes. Non-B DNA also hinders replication, increasing errors and facilitating mutagenesis, yet its contribution to ge...

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Veröffentlicht in:	Nucleic acids research 2021-02, Vol.49 (3), p.1497-1516
Hauptverfasser:	Guiblet, Wilfried M, Cremona, Marzia A, Harris, Robert S, Chen, Di, Eckert, Kristin A, Chiaromonte, Francesca, Huang, Yi-Fei, Makova, Kateryna D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - chemistry Genetic Loci Genetic Variation Genome, Human Genomics Humans Mutation Rate Polymorphism, Single Nucleotide Pongo pygmaeus
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