Peripheral blood monocyte counts are elevated in the pre-diagnostic phase of pancreatic cancer: A population based study
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with improved outcomes. A biomarker with incremental change in the pre-diagnostic phase of the disease would be valuable for early detection. In our clinical experience, we have observed elevated peripheral blood monocyte (PBM)...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019-12, Vol.19 (8), p.1043-1048 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| creator | de la Fuente, Jaime Sharma, Ayush Chari, Suresh Majumder, Shounak |
| description | Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with improved outcomes. A biomarker with incremental change in the pre-diagnostic phase of the disease would be valuable for early detection. In our clinical experience, we have observed elevated peripheral blood monocyte (PBM) counts in PDAC patients at diagnosis. In this study, we aimed to compare PBM counts in PDAC cases and healthy controls at diagnosis and in the 2-year pre-diagnostic period.
Using the Rochester Epidemiology Project database, we identified all patients diagnosed with PDAC between 2000 and 2015 (n = 219) and age-and gender-matched disease-free controls (n = 438). PBM counts and temporal trends were analyzed over a 24 month period before PDAC diagnosis. The groups were compared using Fisher’s exact test and t-test.
At diagnosis, compared to controls PDAC cases more often had monocytosis (23% vs 8%; p |
| doi_str_mv | 10.1016/j.pan.2019.10.002 |
| format | Article |
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Using the Rochester Epidemiology Project database, we identified all patients diagnosed with PDAC between 2000 and 2015 (n = 219) and age-and gender-matched disease-free controls (n = 438). PBM counts and temporal trends were analyzed over a 24 month period before PDAC diagnosis. The groups were compared using Fisher’s exact test and t-test.
At diagnosis, compared to controls PDAC cases more often had monocytosis (23% vs 8%; p < 0.001) and higher mean PBM count (x109/L) (0.73 vs 0.59; p < 0.001). In the 2-year pre-diagnostic period, mean PBM counts were significantly higher in PDAC cases in the interval from 6 months to diagnosis (0.69 vs 0.61; p = 0.03). PDAC cases with monocytosis at diagnosis had a significantly lower median survival (1.9 months vs. 7.6 months; p = 0.001).
Monocytosis is more prevalent in PDAC patients at diagnosis compared to controls and is associated with lower median survival. In a subset of patients, PBM count elevation precedes PDAC diagnosis by 6 months. This novel observation can possibly augment strategies for early diagnosis of PDAC but needs further study.</description><identifier>ISSN: 1424-3903</identifier><identifier>ISSN: 1424-3911</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2019.10.002</identifier><identifier>PMID: 31630918</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Adenocarcinoma ; Age ; Aged ; Biomarker ; Case-Control Studies ; Diabetes ; Diagnosis ; Early detection ; Epidemiology ; Female ; Gender ; Humans ; Hyperglycemia ; Male ; Medical diagnosis ; Medical prognosis ; Middle Aged ; Monocytes ; Monocytosis ; Pancreatic cancer ; Pancreatic ductal adenocarcinoma ; Pancreatic Neoplasms ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - diagnosis ; Peripheral blood ; Population ; Population studies ; Population-based studies ; Prognosis ; Statistical analysis ; Studies ; Survival ; Survival analysis</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019-12, Vol.19 (8), p.1043-1048</ispartof><rights>2019 IAP and EPC</rights><rights>Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.</rights><rights>2019. IAP and EPC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-3f1b844d40f80c5211056db168c4cb9a4096e47386970741bc873f853e842e8d3</citedby><cites>FETCH-LOGICAL-c479t-3f1b844d40f80c5211056db168c4cb9a4096e47386970741bc873f853e842e8d3</cites><orcidid>0000-0002-2069-5052</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31630918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de la Fuente, Jaime</creatorcontrib><creatorcontrib>Sharma, Ayush</creatorcontrib><creatorcontrib>Chari, Suresh</creatorcontrib><creatorcontrib>Majumder, Shounak</creatorcontrib><title>Peripheral blood monocyte counts are elevated in the pre-diagnostic phase of pancreatic cancer: A population based study</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with improved outcomes. A biomarker with incremental change in the pre-diagnostic phase of the disease would be valuable for early detection. In our clinical experience, we have observed elevated peripheral blood monocyte (PBM) counts in PDAC patients at diagnosis. In this study, we aimed to compare PBM counts in PDAC cases and healthy controls at diagnosis and in the 2-year pre-diagnostic period.
Using the Rochester Epidemiology Project database, we identified all patients diagnosed with PDAC between 2000 and 2015 (n = 219) and age-and gender-matched disease-free controls (n = 438). PBM counts and temporal trends were analyzed over a 24 month period before PDAC diagnosis. The groups were compared using Fisher’s exact test and t-test.
At diagnosis, compared to controls PDAC cases more often had monocytosis (23% vs 8%; p < 0.001) and higher mean PBM count (x109/L) (0.73 vs 0.59; p < 0.001). In the 2-year pre-diagnostic period, mean PBM counts were significantly higher in PDAC cases in the interval from 6 months to diagnosis (0.69 vs 0.61; p = 0.03). PDAC cases with monocytosis at diagnosis had a significantly lower median survival (1.9 months vs. 7.6 months; p = 0.001).
Monocytosis is more prevalent in PDAC patients at diagnosis compared to controls and is associated with lower median survival. In a subset of patients, PBM count elevation precedes PDAC diagnosis by 6 months. This novel observation can possibly augment strategies for early diagnosis of PDAC but needs further study.</description><subject>Adenocarcinoma</subject><subject>Age</subject><subject>Aged</subject><subject>Biomarker</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Early detection</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Monocytosis</subject><subject>Pancreatic cancer</subject><subject>Pancreatic ductal adenocarcinoma</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Peripheral blood</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prognosis</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival analysis</subject><issn>1424-3903</issn><issn>1424-3911</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rr6A7xIwIuXHpNOpjtREJbFL1jQg55DOqneydCTtEl6cP69Ncw6qAdPqVQ99VJVLyHPOVtxxrvX29Vs46plXON_xVj7gFxy2cpGaM4fnmMmLsiTUrYItJzrx-RC8E4wzdUl-fkVcpg3kO1EhyklT3cpJneoQF1aYi3UZqAwwd5W8DREWjdA5wyND_YuplKDo_PGFqBppDiOy2CPOYch5Df0ms5pXibMpUgH5DwtdfGHp-TRaKcCz-7fK_L9w_tvN5-a2y8fP99c3zZO9ro2YuSDktJLNirm1jg_W3d-4J1y0g3aSqY7kL1Qne5ZL_ngVC9GtRagZAvKiyvy7qQ7L8MOvINYcVcz57Cz-WCSDebvSgwbc5f2ple6l4yjwKt7gZx-LFCq2YXiYJpshLQU0wrWC73WkiH68h90m5YccT2kuO7btpMSKX6iXE6lZBjPw3Bmjr6arcFDmqOvxxTahj0v_tzi3PHbSATengDAW-4DZFNcALTAhwyuGp_Cf-R_AeuFtDM</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>de la Fuente, Jaime</creator><creator>Sharma, Ayush</creator><creator>Chari, Suresh</creator><creator>Majumder, Shounak</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2069-5052</orcidid></search><sort><creationdate>20191201</creationdate><title>Peripheral blood monocyte counts are elevated in the pre-diagnostic phase of pancreatic cancer: A population based study</title><author>de la Fuente, Jaime ; Sharma, Ayush ; Chari, Suresh ; Majumder, Shounak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-3f1b844d40f80c5211056db168c4cb9a4096e47386970741bc873f853e842e8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Age</topic><topic>Aged</topic><topic>Biomarker</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Early detection</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Monocytosis</topic><topic>Pancreatic cancer</topic><topic>Pancreatic ductal adenocarcinoma</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Peripheral blood</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Prognosis</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Survival</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Fuente, Jaime</creatorcontrib><creatorcontrib>Sharma, Ayush</creatorcontrib><creatorcontrib>Chari, Suresh</creatorcontrib><creatorcontrib>Majumder, Shounak</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de la Fuente, Jaime</au><au>Sharma, Ayush</au><au>Chari, Suresh</au><au>Majumder, Shounak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral blood monocyte counts are elevated in the pre-diagnostic phase of pancreatic cancer: A population based study</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>19</volume><issue>8</issue><spage>1043</spage><epage>1048</epage><pages>1043-1048</pages><issn>1424-3903</issn><issn>1424-3911</issn><eissn>1424-3911</eissn><abstract>Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with improved outcomes. A biomarker with incremental change in the pre-diagnostic phase of the disease would be valuable for early detection. In our clinical experience, we have observed elevated peripheral blood monocyte (PBM) counts in PDAC patients at diagnosis. In this study, we aimed to compare PBM counts in PDAC cases and healthy controls at diagnosis and in the 2-year pre-diagnostic period.
Using the Rochester Epidemiology Project database, we identified all patients diagnosed with PDAC between 2000 and 2015 (n = 219) and age-and gender-matched disease-free controls (n = 438). PBM counts and temporal trends were analyzed over a 24 month period before PDAC diagnosis. The groups were compared using Fisher’s exact test and t-test.
At diagnosis, compared to controls PDAC cases more often had monocytosis (23% vs 8%; p < 0.001) and higher mean PBM count (x109/L) (0.73 vs 0.59; p < 0.001). In the 2-year pre-diagnostic period, mean PBM counts were significantly higher in PDAC cases in the interval from 6 months to diagnosis (0.69 vs 0.61; p = 0.03). PDAC cases with monocytosis at diagnosis had a significantly lower median survival (1.9 months vs. 7.6 months; p = 0.001).
Monocytosis is more prevalent in PDAC patients at diagnosis compared to controls and is associated with lower median survival. In a subset of patients, PBM count elevation precedes PDAC diagnosis by 6 months. This novel observation can possibly augment strategies for early diagnosis of PDAC but needs further study.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>31630918</pmid><doi>10.1016/j.pan.2019.10.002</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2069-5052</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2019-12, Vol.19 (8), p.1043-1048 |
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| subjects | Adenocarcinoma Age Aged Biomarker Case-Control Studies Diabetes Diagnosis Early detection Epidemiology Female Gender Humans Hyperglycemia Male Medical diagnosis Medical prognosis Middle Aged Monocytes Monocytosis Pancreatic cancer Pancreatic ductal adenocarcinoma Pancreatic Neoplasms Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Peripheral blood Population Population studies Population-based studies Prognosis Statistical analysis Studies Survival Survival analysis |
| title | Peripheral blood monocyte counts are elevated in the pre-diagnostic phase of pancreatic cancer: A population based study |
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