Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency

Active DNA demethylation via ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three successive oxidations of 5-methylcytosine (5mC), generating 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), or 5-ca...

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Veröffentlicht in:	Molecular cell 2021-02, Vol.81 (4), p.859-869.e8
Hauptverfasser:	Caldwell, Blake A., Liu, Monica Yun, Prasasya, Rexxi D., Wang, Tong, DeNizio, Jamie E., Leu, N. Adrian, Amoh, Nana Yaa A., Krapp, Christopher, Lan, Yemin, Shields, Emily J., Bonasio, Roberto, Lengner, Christopher J., Kohli, Rahul M., Bartolomei, Marisa S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-carboxycytosine 5-formylcytosine 5-hydroxymethylcytosine 5-Methylcytosine - metabolism 5caC 5fC 5hmC Animals bACE-seq Cellular Reprogramming Dioxygenases DNA demethylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Enhancer Elements, Genetic Epigenesis, Genetic epigenetics Fibroblasts - cytology Fibroblasts - metabolism HEK293 Cells Humans induced pluripotent stem cells iPSCs Mice Mice, Knockout Mutation NIH 3T3 Cells Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism reprogramming ten-eleven translocation TET
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