A single historical substitution drives an increase in acetylcholine receptor complexity

Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from four different, but evolutionarily related, subunits. These subunits assemble with a precise stoichiometry and arrangement such that two chemically distinct agonist-binding sites are formed between specific...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-02, Vol.118 (7), p.1-9
Hauptverfasser:	Emlaw, Johnathon R., Tessier, Christian J. G., McCluskey, Gregory D., McNulty, Melissa S., Sheikh, Yusuf, Burkett, Kelly M., Musgaard, Maria, daCosta, Corrie J. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences
Online-Zugang:	Volltext
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