Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation

The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key signaling pathways such as Hedgehog (HH)/Gli can disrupt tracheoesophageal (TE) morphogenesis and cause life-threatening birth defects (TEDs); however, the underlying cellula...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Developmental cell 2019-12, Vol.51 (6), p.665-674.e6
Hauptverfasser:	Nasr, Talia, Mancini, Pamela, Rankin, Scott A., Edwards, Nicole A., Agricola, Zachary N., Kenny, Alan P., Kinney, Jessica L., Daniels, Keziah, Vardanyan, Jon, Han, Lu, Trisno, Stephen L., Cha, Sang-Wook, Wells, James M., Kofron, Matthew J., Zorn, Aaron M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning - genetics Body Patterning - physiology Digestive System - metabolism EA/TEF Endoderm - metabolism Endosomes - genetics Endosomes - metabolism esophageal atresia Esophagus - embryology Forkhead Transcription Factors - metabolism Gene Expression Regulation, Developmental - genetics Hedgehog Proteins - metabolism Humans Mesoderm - metabolism Morphogenesis - physiology Mutation - genetics Sox2 Xenopus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!