Multivalent, Stabilized Mannose‐6‐Phosphates for the Targeted Delivery of Toll‐Like Receptor Ligands and Peptide Antigens

Mannose‐6‐phosphate (M6P) is recognized by the mannose‐6‐phosphate receptor and plays an important role in the transport of cargo to the endosomes, making it an attractive tool to improve endosomal trafficking of vaccines. We describe herein the assembly of peptide antigen conjugates carrying cluste...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-01, Vol.22 (2), p.434-440
Hauptverfasser:	Reintjens, Niels R. M., Tondini, Elena, Vis, Christopher, McGlinn, Toroa, Meeuwenoord, Nico J., Hogervorst, Tim P., Overkleeft, Herman S., Filippov, Dmitri V., Marel, Gijsbert A., Ossendorp, Ferry, Codée, Jeroen D. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvanticity Alkynes Amino acids Antigen presentation Antigens Assembly C-glycoside Clusters Conjugates Dendritic cells Endosomes Ligands Mannose mannose-6-phosphate receptor peptide conjugates Peptide synthesis Peptides Phosphates Phosphonates Receptors solid-phase peptide synthesis TLR ligands TLR7 protein Toll-like receptors Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!