A Biomimetic DNA‐Based Membrane Gate for Protein‐Controlled Transport of Cytotoxic Drugs

Chemistry is ideally placed to replicate biomolecular structures with tuneable building materials. Of particular interest are molecular nanopores, which transport cargo across membranes, as in DNA sequencing. Advanced nanopores control transport in response to triggers, but this cannot be easily rep...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-01, Vol.60 (4), p.1903-1908
Hauptverfasser:	Lanphere, Conor, Arnott, Patrick M., Jones, Sioned Fôn, Korlova, Katarina, Howorka, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - metabolism Aptamers Bilayers Biological Transport Biomimetics Biosensors Building materials Cargo Construction materials Cytotoxicity Deoxyribonucleic acid DNA DNA - chemistry DNA sequencing DNA structures Drug delivery Drugs Lipid Bilayers - metabolism membrane Membrane proteins Membranes nanopores Nanotechnology Porosity Protein folding Protein transport Proteins Proteins - metabolism Thrombin Transport rate
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