CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome–negative myeloproliferative neoplasms

Discrimination of Philadelphia‐negative myeloproliferative neoplasms (Ph‐MPNs) from reactive hypercytosis and myelofibrosis requires a constellation of testing including driver mutation analysis and bone marrow biopsies. We searched for a biomarker that can more easily distinguish Ph‐MPNs from react...

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Veröffentlicht in:	Cancer science 2021-02, Vol.112 (2), p.884-892
Hauptverfasser:	Morishita, Soji, Yasuda, Hajime, Yamawaki, Saya, Kawaji, Hideya, Itoh, Masayoshi, Edahiro, Yoko, Imai, Misa, Kogo, Yasushi, Tsuneda, Satoshi, Ohsaka, Akimichi, Hayashizaki, Yoshihide, Ito, Masafumi, Araki, Marito, Komatsu, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarker Biomarkers, Tumor - blood Biopsy Blood platelets Bone marrow Chronic myeloid leukemia CREB3L1 Cyclic AMP Response Element-Binding Protein - blood Diagnosis, Differential Gene expression Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Mutation Myelofibrosis Myeloid leukemia Myeloproliferative Disorders - blood Myeloproliferative Disorders - diagnosis Nerve Tissue Proteins - blood Original Patients Philadelphia chromosome Philadelphia‐negative myeloproliferative neoplasms platelet RNA Polycythemia Polycythemia vera Principal components analysis Remission Ribonucleic acid RNA RNA‐seq Software Thrombocytosis Tumors
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