Cellular and functional heterogeneity of the airway epithelium
The airway epithelium protects us from environmental insults, which we encounter with every breath. Not only does it passively filter large particles, it also senses potential danger and alerts other cells, including immune and nervous cells. Together, these tissues orchestrate the most appropriate...
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| Veröffentlicht in: | Mucosal immunology 2021-09, Vol.14 (5), p.978-990 |
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| container_end_page | 990 |
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| container_title | Mucosal immunology |
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| creator | Davis, Jordan D. Wypych, Tomasz P. |
| description | The airway epithelium protects us from environmental insults, which we encounter with every breath. Not only does it passively filter large particles, it also senses potential danger and alerts other cells, including immune and nervous cells. Together, these tissues orchestrate the most appropriate response, balancing the need to eliminate the danger with the risk of damage to the host. Each cell subset within the airway epithelium plays its part, and when impaired, may contribute to the development of respiratory disease. Here we highlight recent advances regarding the cellular and functional heterogeneity along the airway epithelium and discuss how we can use this knowledge to design more effective, targeted therapeutics. |
| doi_str_mv | 10.1038/s41385-020-00370-7 |
| format | Article |
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Not only does it passively filter large particles, it also senses potential danger and alerts other cells, including immune and nervous cells. Together, these tissues orchestrate the most appropriate response, balancing the need to eliminate the danger with the risk of damage to the host. Each cell subset within the airway epithelium plays its part, and when impaired, may contribute to the development of respiratory disease. 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Here we highlight recent advances regarding the cellular and functional heterogeneity along the airway epithelium and discuss how we can use this knowledge to design more effective, targeted therapeutics.</description><subject>Allergology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Asthma</subject><subject>Biological Variation, Population</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cystic fibrosis</subject><subject>Disease Susceptibility</subject><subject>Drug Development</subject><subject>Epithelial Cells - immunology</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelium</subject><subject>Gastroenterology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Homeostasis</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Immunity, Mucosal</subject><subject>Immunology</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Molecular Targeted Therapy</subject><subject>Neuropeptides</subject><subject>Neutrophils</subject><subject>Proteins</subject><subject>Respiratory diseases</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Mucosa - cytology</subject><subject>Respiratory Mucosa - physiology</subject><subject>Respiratory system</subject><subject>Respiratory tract</subject><subject>Review</subject><subject>Review Article</subject><subject>Sepsis</subject><subject>Signal Transduction</subject><subject>Smoking</subject><subject>Stem cells</subject><subject>Tumor necrosis factor-TNF</subject><issn>1933-0219</issn><issn>1935-3456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyxQJNaBccaPZFMJVbykSmxgbTnppE2VJsVOQP17DC0FNqxsz71zZ3wYO-dwxQHTay84pjKGBGIA1BDrAzbkGcoYhVSHX3cMMs8G7MT7JYACkHjMBogKUiXlkI0nVNd9bV1km1lU9k3RVW1j62hBHbl2Tg1V3SZqy6hbUGQr9243Ea2r8KqrfnXKjkpbezrbnSP2cnf7PHmIp0_3j5ObaVxIAV0skeuZSGyJKQngqKVVWhEXKhNE0grFQeZUaJ0UKs_xc3-VCpoleajZHEdsvM1d9_mKZgU1nbO1WbtqZd3GtLYyf5WmWph5-2Z0mqFKZAi43AW49rUn35ll27vwUW8SqRBUkmkeXMnWVbjWe0flfgIH88ncbJmbwNx8MTc6NF383m3f8g05GHBr8EFq5uR-Zv8T-wGiQYzy</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Davis, Jordan D.</creator><creator>Wypych, Tomasz P.</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0558-7923</orcidid></search><sort><creationdate>20210901</creationdate><title>Cellular and functional heterogeneity of the airway epithelium</title><author>Davis, Jordan D. ; Wypych, Tomasz P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-5317d42af38e401375a676e14694ee5a46105bec772c6bb33456684ed2bc77ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Asthma</topic><topic>Biological Variation, Population</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cystic fibrosis</topic><topic>Disease Susceptibility</topic><topic>Drug Development</topic><topic>Epithelial Cells - immunology</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelium</topic><topic>Gastroenterology</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Homeostasis</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Immunity, Mucosal</topic><topic>Immunology</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Molecular Targeted Therapy</topic><topic>Neuropeptides</topic><topic>Neutrophils</topic><topic>Proteins</topic><topic>Respiratory diseases</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Mucosa - cytology</topic><topic>Respiratory Mucosa - physiology</topic><topic>Respiratory system</topic><topic>Respiratory tract</topic><topic>Review</topic><topic>Review Article</topic><topic>Sepsis</topic><topic>Signal Transduction</topic><topic>Smoking</topic><topic>Stem cells</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Jordan D.</creatorcontrib><creatorcontrib>Wypych, Tomasz P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mucosal immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Jordan D.</au><au>Wypych, Tomasz P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular and functional heterogeneity of the airway epithelium</atitle><jtitle>Mucosal immunology</jtitle><stitle>Mucosal Immunol</stitle><addtitle>Mucosal Immunol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>14</volume><issue>5</issue><spage>978</spage><epage>990</epage><pages>978-990</pages><issn>1933-0219</issn><eissn>1935-3456</eissn><abstract>The airway epithelium protects us from environmental insults, which we encounter with every breath. 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| ispartof | Mucosal immunology, 2021-09, Vol.14 (5), p.978-990 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Allergology Animals Antibodies Asthma Biological Variation, Population Biomarkers Biomedical and Life Sciences Biomedicine Chronic obstructive pulmonary disease Cystic fibrosis Disease Susceptibility Drug Development Epithelial Cells - immunology Epithelial Cells - metabolism Epithelium Gastroenterology Gene Expression Regulation Genes Homeostasis Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Humans Hyperplasia Immunity, Mucosal Immunology Kinases Lung cancer Medical prognosis Molecular Targeted Therapy Neuropeptides Neutrophils Proteins Respiratory diseases Respiratory distress syndrome Respiratory Mucosa - cytology Respiratory Mucosa - physiology Respiratory system Respiratory tract Review Review Article Sepsis Signal Transduction Smoking Stem cells Tumor necrosis factor-TNF |
| title | Cellular and functional heterogeneity of the airway epithelium |
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