Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells

Several natural products have been demonstrated to both enhance the anti-tumor efficacy and alleviate the side effects of conventional chemotherapy drugs. Rhein, a main constituent of the Chinese herb rhubarb, has been shown to induce apoptosis in various cancer types. However, the exact pharmacolog...

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Veröffentlicht in:	International journal of biological sciences 2021-01, Vol.17 (2), p.589-602
Hauptverfasser:	Liu, Yuhui, Shi, Chengjian, He, Zheng, Zhu, Feng, Wang, Min, He, Ruizhi, Zhao, Chunle, Shi, Xiuhui, Zhou, Min, Pan, Shutao, Gao, Yang, Li, Xu, Qin, Renyi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Anthraquinones - pharmacology Anthraquinones - therapeutic use Antibodies Anticancer properties Antineoplastic Agents - therapeutic use Apoptosis Cancer Cancer therapies Caspase Cell cycle Cell Line, Tumor Cell proliferation Chemotherapy Combined treatment Cytochrome Deactivation Drug resistance Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Drug Synergism Drugs Flow cytometry G1 phase Humans Inactivation Kinases Mitochondria N-Acetyl-L-cysteine Natural products Oxaliplatin Oxaliplatin - therapeutic use Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pheochromocytoma cells Phosphatidylinositol 3-Kinases - metabolism Phytotherapy Proteins Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Reagents Research Paper Rheum Rhubarb Sensitivity enhancement Side effects Tumors
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