Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer

Background Carcinoembryonic antigen is overexpressed in colorectal cancer (CRC), making it an optimal target for fluorescence imaging. A phase I/II study was designed to determine the optimal imaging dose of SGM-101 for intraoperative fluorescence imaging of primary and recurrent CRC. Methods Patien...

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Veröffentlicht in:	Annals of surgical oncology 2021-03, Vol.28 (3), p.1832-1844
Hauptverfasser:	de Valk, Kim S., Deken, Marion M., Schaap, Dennis P., Meijer, Ruben P., Boogerd, Leonora S., Hoogstins, Charlotte E., van der Valk, Maxime J., Kamerling, Ingrid M., Bhairosingh, Shadhvi S., Framery, Bérénice, Hilling, Denise E., Peeters, Koen C., Holman, Fabian A., Kusters, Miranda, Rutten, Harm J., Cailler, Françoise, Burggraaf, Jacobus, Vahrmeijer, Alexander L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoembryonic Antigen Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - drug therapy Female Fluorescence Humans Infrared imaging systems Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - diagnostic imaging Oncology Optical Imaging Radiation therapy Surgery Surgical Oncology Translational Research Tumors
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