Letrozole targets the human ether‐a‐go‐go–related gene potassium current in glioblastoma

Aberrant expression of human ether‐a‐go‐go–related gene (hERG) potassium channels has been implicated in the pathophysiology of glioblastoma (GBM). Letrozole has demonstrated efficacy in pre‐clinical GBM models. The objective of this research was to assess the potential for hERG inhibition by letroz...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2021-03, Vol.128 (3), p.357-365
Hauptverfasser:	Shugg, Tyler, Dave, Nimita, Amarh, Enoch, Assiri, Abdullah A., Pollok, Karen E., Overholser, Brian R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Aromatase Biomarkers Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain Neoplasms - pathology carcinogenesis cardiac arrhythmias Cell growth Cell Line, Tumor Cell proliferation Dimethyl sulfoxide Dose-Response Relationship, Drug Electrophysiology ESR1 protein Ether-A-Go-Go Potassium Channels - antagonists & inhibitors Gene expression Genomes Glioblastoma Glioblastoma - drug therapy Glioblastoma - mortality Glioblastoma - pathology hERG human ether‐a‐go‐go–related gene Humans ion channels as drug targets letrozole Letrozole - pharmacology Letrozole - therapeutic use Potassium Potassium channels
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