GLP‑1 Val8: A Biased GLP‑1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

Biased ligands that selectively confer activity in one pathway over another are pharmacologically important because biased signaling may reduce on-target side effects and improve drug efficacy. Here, we describe an N-terminal modification in the incretin hormone glucagon-like peptide (GLP-1) that al...

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Veröffentlicht in:	ACS pharmacology & translational science 2021-02, Vol.4 (1), p.296-313
Hauptverfasser:	van der Velden, Wijnand J. C, Smit, Florent X, Christiansen, Charlotte B, Møller, Thor C, Hjortø, Gertrud M, Larsen, Olav, Schiellerup, Sine P, Bräuner-Osborne, Hans, Holst, Jens J, Hartmann, Bolette, Frimurer, Thomas M, Rosenkilde, Mette M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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