Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades

Introduction Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material f...

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Veröffentlicht in:Ophthalmology and Therapy 2021-03, Vol.10 (1), p.165-174
Hauptverfasser: Wang, Qiang, Yildirim, Timur M., Schickhardt, Sonja K., Łabuz, Grzegorz, Khoramnia, Ramin, Merz, Patrick R., Son, Hyeck-Soo, Munro, Donald J., Friedmann, Elfriede, Auffarth, Gerd U.
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container_end_page 174
container_issue 1
container_start_page 165
container_title Ophthalmology and Therapy
container_volume 10
creator Wang, Qiang
Yildirim, Timur M.
Schickhardt, Sonja K.
Łabuz, Grzegorz
Khoramnia, Ramin
Merz, Patrick R.
Son, Hyeck-Soo
Munro, Donald J.
Friedmann, Elfriede
Auffarth, Gerd U.
description Introduction Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day. Methods In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm 2 ) was determined in the central part of each IOL optic and compared between the groups. Results The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm 2 . The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm 2 . Conclusions A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.
doi_str_mv 10.1007/s40123-020-00329-8
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The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day. Methods In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm 2 ) was determined in the central part of each IOL optic and compared between the groups. Results The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm 2 . The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm 2 . Conclusions A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.</description><identifier>ISSN: 2193-8245</identifier><identifier>EISSN: 2193-6528</identifier><identifier>DOI: 10.1007/s40123-020-00329-8</identifier><identifier>PMID: 33544374</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Acrylic resins ; Internal Medicine ; Intraocular lenses ; Materials ; Mechanical properties ; Medicine ; Medicine &amp; Public Health ; Ophthalmology ; Optical properties ; Original Research</subject><ispartof>Ophthalmology and Therapy, 2021-03, Vol.10 (1), p.165-174</ispartof><rights>The Author(s) 2021</rights><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-482cc5bd691787e91e6891a6fee47ee35e1e67a7d1227b531eb1365e4849b65c3</citedby><cites>FETCH-LOGICAL-c513t-482cc5bd691787e91e6891a6fee47ee35e1e67a7d1227b531eb1365e4849b65c3</cites><orcidid>0000-0002-6927-5251 ; 0000-0002-3687-5082</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886932/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886932/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33544374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qiang</creatorcontrib><creatorcontrib>Yildirim, Timur M.</creatorcontrib><creatorcontrib>Schickhardt, Sonja K.</creatorcontrib><creatorcontrib>Łabuz, Grzegorz</creatorcontrib><creatorcontrib>Khoramnia, Ramin</creatorcontrib><creatorcontrib>Merz, Patrick R.</creatorcontrib><creatorcontrib>Son, Hyeck-Soo</creatorcontrib><creatorcontrib>Munro, Donald J.</creatorcontrib><creatorcontrib>Friedmann, Elfriede</creatorcontrib><creatorcontrib>Auffarth, Gerd U.</creatorcontrib><title>Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades</title><title>Ophthalmology and Therapy</title><addtitle>Ophthalmol Ther</addtitle><addtitle>Ophthalmol Ther</addtitle><description>Introduction Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day. Methods In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm 2 ) was determined in the central part of each IOL optic and compared between the groups. Results The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm 2 . The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm 2 . Conclusions A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.</description><subject>Acrylic resins</subject><subject>Internal Medicine</subject><subject>Intraocular lenses</subject><subject>Materials</subject><subject>Mechanical properties</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Ophthalmology</subject><subject>Optical properties</subject><subject>Original Research</subject><issn>2193-8245</issn><issn>2193-6528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9Ustu1DAUjRCIVqU_wAJ5ySbFz9jZII36lgYVJGBrOc7N1FViD7aD1B3fwI7f65fgaYYKNqxs3fPQfZyqek3wCcFYvkscE8pqTHGNMaNtrZ5Vh5S0rG4EVc_3f0W5OKiOU7rDuPCVaDl_WR0wJjhnkh9WPz_Nxmc3OGuyCx6FAeVbQNcefXU5BvQxQu_SNiT3COeALkeXMnjnN-gixGmROY9uPKAPxs-DsXmOEB9-_EpoZeP96Gzxy9EEO48mojX4BKlwe9jpztwwQASf0RnYUkuvqheDGRMc79-j6svF-efTq3p9c3l9ulrXVhCWa66otaLrm5ZIJaEl0KiWmGYA4BKACSgVaWRPKJWdYAQ6whoBXPG2a4RlR9X7xXc7dxP0FnY9jnob3WTivQ7G6X8R7271JnzXUqmmZbQYvN0bxPBthpT15JKFcTQewpw05UoSITlpCvVkoW7MCNr5IRRHa3bzTs4GD4Mr9VU5HRYCt20R0EVgY0gpwvDUF8F6FwC9BECXAOjHAGhVRG_-nuhJ8ufchcAWQiqQ30DUd2GOvmz5f7a_AXX1vyw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Wang, Qiang</creator><creator>Yildirim, Timur M.</creator><creator>Schickhardt, Sonja K.</creator><creator>Łabuz, Grzegorz</creator><creator>Khoramnia, Ramin</creator><creator>Merz, Patrick R.</creator><creator>Son, Hyeck-Soo</creator><creator>Munro, Donald J.</creator><creator>Friedmann, Elfriede</creator><creator>Auffarth, Gerd U.</creator><general>Springer Healthcare</general><general>Springer</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6927-5251</orcidid><orcidid>https://orcid.org/0000-0002-3687-5082</orcidid></search><sort><creationdate>20210301</creationdate><title>Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades</title><author>Wang, Qiang ; Yildirim, Timur M. ; Schickhardt, Sonja K. ; Łabuz, Grzegorz ; Khoramnia, Ramin ; Merz, Patrick R. ; Son, Hyeck-Soo ; Munro, Donald J. ; Friedmann, Elfriede ; Auffarth, Gerd U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-482cc5bd691787e91e6891a6fee47ee35e1e67a7d1227b531eb1365e4849b65c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acrylic resins</topic><topic>Internal Medicine</topic><topic>Intraocular lenses</topic><topic>Materials</topic><topic>Mechanical properties</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Ophthalmology</topic><topic>Optical properties</topic><topic>Original Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qiang</creatorcontrib><creatorcontrib>Yildirim, Timur M.</creatorcontrib><creatorcontrib>Schickhardt, Sonja K.</creatorcontrib><creatorcontrib>Łabuz, Grzegorz</creatorcontrib><creatorcontrib>Khoramnia, Ramin</creatorcontrib><creatorcontrib>Merz, Patrick R.</creatorcontrib><creatorcontrib>Son, Hyeck-Soo</creatorcontrib><creatorcontrib>Munro, Donald J.</creatorcontrib><creatorcontrib>Friedmann, Elfriede</creatorcontrib><creatorcontrib>Auffarth, Gerd U.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ophthalmology and Therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qiang</au><au>Yildirim, Timur M.</au><au>Schickhardt, Sonja K.</au><au>Łabuz, Grzegorz</au><au>Khoramnia, Ramin</au><au>Merz, Patrick R.</au><au>Son, Hyeck-Soo</au><au>Munro, Donald J.</au><au>Friedmann, Elfriede</au><au>Auffarth, Gerd U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades</atitle><jtitle>Ophthalmology and Therapy</jtitle><stitle>Ophthalmol Ther</stitle><addtitle>Ophthalmol Ther</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>10</volume><issue>1</issue><spage>165</spage><epage>174</epage><pages>165-174</pages><issn>2193-8245</issn><eissn>2193-6528</eissn><abstract>Introduction Foldable hydrophobic acrylic intraocular lenses (IOLs) are prone to develop a long-term postoperative material change called glistenings. The aim of this study was to investigate the changes in the predisposition for glistening formation in one type of hydrophobic acrylic IOL material from its introduction to the present day. Methods In a laboratory setup, an in vitro model was used to induce glistenings in hydrophobic acrylic IOLs manufactured by one company (Alcon, Fort Worth, TX, USA) in different years: 23 1990s-manufacture hydrophobic acrylic three-piece IOLs (MA30BA/MA60AC) that were explanted in 1996 and 1997, and five of each of the newer AcrySof IOL models (MA60AC, SA60AT, TFNT00 and SN60WF) from 2014 to 2017. Furthermore, five Clareon (SY60WF) IOLs were put through the same accelerated aging procedure. The number of microvacuoles per square millimeter (MV/mm 2 ) was determined in the central part of each IOL optic and compared between the groups. Results The mean number of MV was highest in the 1990s-manufacture Alcon acrylic IOLs, with 1289 (± 738) MV/mm 2 . The number decreased to 650 (± 101), 192 (± 105), 175 (± 112) and 47 (± 26) for MA60AC, SA60AT, TFNT00 and SN60WF, respectively. The lowest count was obtained in the Clareon group, with 1 (± 1) MV/mm 2 . Conclusions A high number of glistenings was induced in the explanted IOLs from the 1990s. The propensity for glistening formation decreased considerably after that decade and now in current use. Even though in vitro glistening formation in today’s AcrySof material was low, the Clareon material was essentially glistenings-free.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>33544374</pmid><doi>10.1007/s40123-020-00329-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6927-5251</orcidid><orcidid>https://orcid.org/0000-0002-3687-5082</orcidid><oa>free_for_read</oa></addata></record>
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source DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Acrylic resins
Internal Medicine
Intraocular lenses
Materials
Mechanical properties
Medicine
Medicine & Public Health
Ophthalmology
Optical properties
Original Research
title Quantification of the In Vitro Predisposition to Glistening Formation in One Manufacturer’s Acrylic Intraocular Lenses Made in Different Decades
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