Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study
Summary The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 ( n =966), using Propensity Score Matching to adjust for potenti...
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| Veröffentlicht in: | Current medical science 2021-02, Vol.41 (1), p.24-30 |
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| creator | Liang, Meng-yuan Chen, Ping He, Miao Tang, Jian Li, Hui He, Xin-liang Zhou, Ya-ya Feng, Si-wei Xue, Yu-e Liu, Yao Ma, Yan-ling Zhang, Jian-chu |
| description | Summary
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (
n
=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (
n
=289) and the non-corticosteroids group (
n
=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality. |
| doi_str_mv | 10.1007/s11596-021-2313-6 |
| format | Article |
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The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (
n
=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (
n
=289) and the non-corticosteroids group (
n
=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.</description><identifier>ISSN: 2096-5230</identifier><identifier>ISSN: 2523-899X</identifier><identifier>ISSN: 1672-0733</identifier><identifier>EISSN: 2523-899X</identifier><identifier>DOI: 10.1007/s11596-021-2313-6</identifier><identifier>PMID: 33582901</identifier><language>eng</language><publisher>Wuhan: Huazhong University of Science and Technology</publisher><subject>Adrenal Cortex Hormones - administration & dosage ; Adrenal Cortex Hormones - therapeutic use ; Aged ; Chemotherapy, Adjuvant ; COVID-19 Drug Treatment ; Female ; Hospital Mortality ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Propensity Score ; Retrospective Studies ; SARS-CoV-2 - drug effects ; SARS-CoV-2 - physiology ; Virus Shedding - drug effects</subject><ispartof>Current medical science, 2021-02, Vol.41 (1), p.24-30</ispartof><rights>Huazhong University of Science and Technology 2021</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-18dc07d7b93b8e83fb0f15a6f0e2bfe6aadbfeb81edecf74ab6b24699fc566be3</citedby><cites>FETCH-LOGICAL-c478t-18dc07d7b93b8e83fb0f15a6f0e2bfe6aadbfeb81edecf74ab6b24699fc566be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/tjykdxxb-e/tjykdxxb-e.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11596-021-2313-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11596-021-2313-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33582901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Meng-yuan</creatorcontrib><creatorcontrib>Chen, Ping</creatorcontrib><creatorcontrib>He, Miao</creatorcontrib><creatorcontrib>Tang, Jian</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>He, Xin-liang</creatorcontrib><creatorcontrib>Zhou, Ya-ya</creatorcontrib><creatorcontrib>Feng, Si-wei</creatorcontrib><creatorcontrib>Xue, Yu-e</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Ma, Yan-ling</creatorcontrib><creatorcontrib>Zhang, Jian-chu</creatorcontrib><title>Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study</title><title>Current medical science</title><addtitle>CURR MED SCI</addtitle><addtitle>Curr Med Sci</addtitle><description>Summary
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (
n
=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (
n
=289) and the non-corticosteroids group (
n
=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.</description><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Aged</subject><subject>Chemotherapy, Adjuvant</subject><subject>COVID-19 Drug Treatment</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2 - drug effects</subject><subject>SARS-CoV-2 - physiology</subject><subject>Virus Shedding - drug effects</subject><issn>2096-5230</issn><issn>2523-899X</issn><issn>1672-0733</issn><issn>2523-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vVCEUhonR2Kb2B7gxLE3MVT7mcsGFSTN-JjU2aU3cEeAeZqgzMAVu2_n30txadeHqHHKe8_LCi9BzSl5TQoY3hdJeiY4w2jFOeSceoUPWM95JpX48bj1p03YmB-i4lGAJp0xwKtlTdMB5L5ki9BD5Zco1uFQq5BTGgi8ymLqFWHHy-MzU0NqCb0Jd44amaK5Dngp-HwqYApgRqt7iE3yW0w5iCXWPz13KgL-a6tYhrvB5ncb9M_TEm02B4_t6hL5__HCx_Nydfvv0ZXly2rnFIGtH5ejIMA5WcStBcm-Jp70RngCzHoQxYytWUhjB-WFhrLBsIZTyrhfCAj9C72bd3WS3MLpmPpuN3uWwNXmvkwn630kMa71K13qQkiraN4FXs8CNid7Elb5MU47Nsq6X-5_j7a3VwNqfk5YBb_TL--tyupqgVL0NxcFmYyKkqWi2kKpXkijaUDqjLqdSMvgHU5Tou0D1HKhu4vouUC3azou_X_Ow8Tu-BrAZKG0UV5D_2P2_6i-wRK6k</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Liang, Meng-yuan</creator><creator>Chen, Ping</creator><creator>He, Miao</creator><creator>Tang, Jian</creator><creator>Li, Hui</creator><creator>He, Xin-liang</creator><creator>Zhou, Ya-ya</creator><creator>Feng, Si-wei</creator><creator>Xue, Yu-e</creator><creator>Liu, Yao</creator><creator>Ma, Yan-ling</creator><creator>Zhang, Jian-chu</creator><general>Huazhong University of Science and Technology</general><general>Department of Respiratory and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20210201</creationdate><title>Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study</title><author>Liang, Meng-yuan ; Chen, Ping ; He, Miao ; Tang, Jian ; Li, Hui ; He, Xin-liang ; Zhou, Ya-ya ; Feng, Si-wei ; Xue, Yu-e ; Liu, Yao ; Ma, Yan-ling ; Zhang, Jian-chu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-18dc07d7b93b8e83fb0f15a6f0e2bfe6aadbfeb81edecf74ab6b24699fc566be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Aged</topic><topic>Chemotherapy, Adjuvant</topic><topic>COVID-19 Drug Treatment</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2 - drug effects</topic><topic>SARS-CoV-2 - physiology</topic><topic>Virus Shedding - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Meng-yuan</creatorcontrib><creatorcontrib>Chen, Ping</creatorcontrib><creatorcontrib>He, Miao</creatorcontrib><creatorcontrib>Tang, Jian</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>He, Xin-liang</creatorcontrib><creatorcontrib>Zhou, Ya-ya</creatorcontrib><creatorcontrib>Feng, Si-wei</creatorcontrib><creatorcontrib>Xue, Yu-e</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Ma, Yan-ling</creatorcontrib><creatorcontrib>Zhang, Jian-chu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Meng-yuan</au><au>Chen, Ping</au><au>He, Miao</au><au>Tang, Jian</au><au>Li, Hui</au><au>He, Xin-liang</au><au>Zhou, Ya-ya</au><au>Feng, Si-wei</au><au>Xue, Yu-e</au><au>Liu, Yao</au><au>Ma, Yan-ling</au><au>Zhang, Jian-chu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study</atitle><jtitle>Current medical science</jtitle><stitle>CURR MED SCI</stitle><addtitle>Curr Med Sci</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>41</volume><issue>1</issue><spage>24</spage><epage>30</epage><pages>24-30</pages><issn>2096-5230</issn><issn>2523-899X</issn><issn>1672-0733</issn><eissn>2523-899X</eissn><abstract>Summary
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (
n
=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (
n
=289) and the non-corticosteroids group (
n
=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.</abstract><cop>Wuhan</cop><pub>Huazhong University of Science and Technology</pub><pmid>33582901</pmid><doi>10.1007/s11596-021-2313-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2096-5230 |
| ispartof | Current medical science, 2021-02, Vol.41 (1), p.24-30 |
| issn | 2096-5230 2523-899X 1672-0733 2523-899X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7881915 |
| source | MEDLINE; SpringerLink Journals; Alma/SFX Local Collection |
| subjects | Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Aged Chemotherapy, Adjuvant COVID-19 Drug Treatment Female Hospital Mortality Humans Male Medicine Medicine & Public Health Middle Aged Propensity Score Retrospective Studies SARS-CoV-2 - drug effects SARS-CoV-2 - physiology Virus Shedding - drug effects |
| title | Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study |
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