ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

The response to poly(ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It remains unclear, however, if the established role of PARP in promoting chromatin accessibility impacts viability in these set...

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Veröffentlicht in:	Nature cell biology 2021-02, Vol.23 (2), p.160-171
Hauptverfasser:	Verma, Priyanka, Zhou, Yeqiao, Cao, Zhendong, Deraska, Peter V., Deb, Moniher, Arai, Eri, Li, Weihua, Shao, Yue, Puentes, Laura, Li, Yiwen, Patankar, Sonali, Mach, Robert H., Faryabi, Robert B., Shi, Junwei, Greenberg, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/31 631/337/100 631/337/1427/2190 631/67/1059/2326 Accessibility Adenosine diphosphate Biology Biomedical and Life Sciences BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer Cancer Cancer Research Cell Biology Cell Line, Tumor Cell Proliferation - drug effects Chromatin Chromatin - metabolism Chromatin Assembly and Disassembly - drug effects Chromatin remodeling Chromosome Aberrations CRISPR CRISPR-Cas Systems - genetics Damage accumulation Deoxyribonucleic acid Developmental Biology DNA DNA biosynthesis DNA damage DNA Helicases - chemistry DNA Helicases - metabolism DNA repair DNA Repair - drug effects DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Drug dosages Drug therapy Enzyme inhibitors Enzymes Epistasis, Genetic - drug effects Genetic aspects Genomic Instability Green Fluorescent Proteins - metabolism Health aspects Homologous recombination Homologous Recombination - drug effects Homologous Recombination - genetics Homology Humans Hypersensitivity Inhibitors Life Sciences Medicine Methyl Methanesulfonate Mutation Mutation - genetics Phthalazines - pharmacology Piperazines - pharmacology Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - metabolism Protein Domains Proteins Repair Ribose Sensitivity enhancement Stem Cells Structure Targeted cancer therapy Toxicity Transferases
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