Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway

Objective. To evaluate the therapeutic effect of epigallocatechin gallate (EGCG) on precancerous lesions of gastric carcinoma (PLGC) and to determine whether EGCG protects against PLGC by regulating PI3K/Akt/mTOR pathway. Methods. Twenty-four male Wistar rats were randomly divided into 3 groups: nor...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2021, Vol.2021, p.8846813-10
Hauptverfasser:	Zhu, Feiye, Xu, Yanli, Pan, Jieli, Li, Meiya, Chen, Fangming, Xie, Guanqun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animal models Apoptosis Atrophy Body weight Caspase-3 Epigallocatechin gallate Gastric cancer Gastric mucosa Hyperplasia Immunoblotting Intestine Laboratory animals Lesions Medical prognosis Metaplasia mRNA Polymerase chain reaction Proteins PTEN protein Rodents Salicylic acid Sodium salicylate TOR protein
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