Synthesis of Structurally Diverse 3‑, 4‑, 5‑, and 6‑Membered Heterocycles from Diisopropyl Iminomalonates and Soft C‑Nucleophiles

Herein, we present a general synthetic strategy for the preparation of 3-, 4-, 5-, and 6-membered heterocyclic unnatural amino acid derivatives by exploiting facile Mannich-type reactions between readily available N-alkyl- and N-aryl-substituted diisopropyl iminomalonates and a wide range of soft an...

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Veröffentlicht in:	Journal of organic chemistry 2019-06, Vol.84 (11), p.7066-7099
Hauptverfasser:	Kattamuri, Padmanabha V, Bhakta, Urmibhusan, Siriwongsup, Surached, Kwon, Doo-Hyun, Alemany, Lawrence B, Yousufuddin, Muhammed, Ess, Daniel H, Kürti, László
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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