Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures

Organoids (ORGs) are increasingly used as models of cerebral cortical development. Here, we compared transcriptome and cellular phenotypes between telencephalic ORGs and monolayers (MONs) generated in parallel from three biologically distinct induced pluripotent stem cell (iPSC) lines. Multiple read...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Stem cell reports 2021-02, Vol.16 (2), p.264-280
Hauptverfasser:	Scuderi, Soraya, Altobelli, Giovanna G., Cimini, Vincenzo, Coppola, Gianfilippo, Vaccarino, Flora M.
Format:	Artikel
Sprache:	eng
Schlagworte:	cerebral cortex human iPSCs network analyses Notch signaling organoids proteomics RNA-seq
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!