Cold sensitivity of the SARS-CoV-2 spike ectodomain

The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its receptor binding domain in two conformations, the receptor-accessible ‘up’ or receptor-inaccessible ‘down’ states. Here we report that the commonly used stabilized S ectodomain construct ‘2P’ is sensiti...

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Veröffentlicht in:	Nature structural & molecular biology 2021-02, Vol.28 (2), p.128-131
Hauptverfasser:	Edwards, Robert J., Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H., Sprenz, Jordan, Williams, Wilton, Saunders, Kevin O., Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Munir Alam, S., Haynes, Barton F., Acharya, Priyamvada
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 101/28 631/1647/328/2082 631/45/612/1237 82 82/103 82/16 82/29 82/80 82/83 Antibodies, Viral - chemistry Biochemistry Biological Microscopy Biomedical and Life Sciences Brief Communication Cold Cold storage Cold Temperature Cold weather construction Conformation Coronaviruses COVID-19 COVID-19 vaccines COVID-19 Vaccines - chemistry Cryoelectron Microscopy Enzyme-Linked Immunosorbent Assay Humans Life Sciences Membrane Biology Physiological aspects Protein Denaturation Protein Domains Protein Stability Protein Structure Proteins Receptors Sensitivity Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - ultrastructure Spikes Structure Structure-function relationships Surface Plasmon Resonance Thermal properties Vaccine development Vaccines Viral proteins Virus research
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