The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats

The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats

The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Adult male Wistar rats received Intraperitoneal (IP)...

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Veröffentlicht in:Basic and clinical neuroscience 2020-07, Vol.11 (4), p.457-464
Hauptverfasser: Soleimani Asl, Sara, Ghasemi Moravej, Fahimeh, Kowsari, Golshad, Farhadi, Mohammad Hassan, Pourhaydar, Bagher, Ghasemi Hamidabadi, Hatef, Mehdizadeh, Mehdi
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container_end_page 464
container_issue 4
container_start_page 457
container_title Basic and clinical neuroscience
container_volume 11
creator Soleimani Asl, Sara
Ghasemi Moravej, Fahimeh
Kowsari, Golshad
Farhadi, Mohammad Hassan
Pourhaydar, Bagher
Ghasemi Hamidabadi, Hatef
Mehdizadeh, Mehdi
description The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses. MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related. MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
doi_str_mv 10.32598/bcn.9.10.420
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title The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats
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