Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species

The precise mechanism of intercellular communication between cancer cells following radiation exposure is unclear. Exosomes are membrane‑enclosed small vesicles comprising lipid bilayers and are mediators of intercellular communication that transport a variety of intracellular components, including...

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Veröffentlicht in:	Oncology reports 2021-04, Vol.45 (4), p.1, Article 13
Hauptverfasser:	Nakaoka, Ai, Nakahana, Makiko, Inubushi, Sachiko, Akasaka, Hiroaki, Salah, Mohammed, Fujita, Yoshiko, Kubota, Hikaru, Hassan, Mennaallah, Nishikawa, Ryo, Mukumoto, Naritoshi, Ishihara, Takeaki, Miyawaki, Daisuke, Sasayama, Takashi, Sasaki, Ryohei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - metabolism Apoptosis Biotechnology industry Brownian motion Cancer Cancer cells Care and treatment Cell Communication - physiology Cell Communication - radiation effects Cell culture Cell growth Cell Line, Tumor Cell Survival - physiology Communication Cytokines Deoxyribonucleic acid DNA DNA Damage DNA microarrays Exosomes - genetics Exosomes - metabolism Exosomes - radiation effects Homeostasis Humans Methylene blue MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - radiotherapy Pharmaceutical industry Polymer industry Proteins Radiation Radiation Tolerance Reactive oxygen species Reactive Oxygen Species - metabolism Scientific equipment and supplies industry Superoxide Superoxide Dismutase-1 - biosynthesis Superoxide Dismutase-1 - metabolism
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