Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a therapeutic target in cancer. Here, we report the unexpected finding that median expression of SCD is low in glioblastoma relative to normal brain...

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Veröffentlicht in:	Science advances 2021-02, Vol.7 (7)
Hauptverfasser:	Oatman, Nicole, Dasgupta, Nupur, Arora, Priyanka, Choi, Kwangmin, Gawali, Mruniya V, Gupta, Nishtha, Parameswaran, Sreeja, Salomone, Joseph, Reisz, Julie A, Lawler, Sean, Furnari, Frank, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Gudelsky, Gary, Desai, Pankaj, Gebelein, Brian, Weirauch, Matthew T, D'Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cell Biology Drug Resistance, Neoplasm - genetics Health and Medicine Humans Lipid Metabolism Lipogenesis Mice Neoplasms - drug therapy Neoplasms - genetics Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism SciAdv r-articles Stearoyl-CoA Desaturase - antagonists & inhibitors Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism
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