Sperm microRNAs confer depression susceptibility to offspring
Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molec...
Gespeichert in:
| Veröffentlicht in: | Science advances 2021-02, Vol.7 (7) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | |
| container_title | Science advances |
| container_volume | 7 |
| creator | Wang, Yanbo Chen, Zhang-Peng Hu, Huanhuan Lei, Jieqiong Zhou, Zhen Yao, Bing Chen, Li Liang, Gaoli Zhan, Shoubin Zhu, Xiaoju Jin, Fangfang Ma, Rujun Zhang, Jun Liang, Hongwei Xing, Ming Chen, Xiao-Rui Zhang, Chen-Yu Zhu, Jing-Ning Chen, Xi |
| description | Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression. |
| doi_str_mv | 10.1126/sciadv.abd7605 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7875527</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2488550397</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-61104758be966cd9c203f30d1809f8dda9e21bd457bd6e5a83760c7af51254ea3</originalsourceid><addsrcrecordid>eNpVkElrwzAQhUVpaUKaa4_Fx16cSpa1-NBCCN0gtNDlLGQtqYptuZIdyL-vQ9KQnmZg3ryZ9wFwieAMoYzeROWkXs9kqRmF5ASMM8xImpGcnx71IzCN8RtCiHJKCSrOwQhjQnnO4Rjcvrcm1EntVPBvL_OYKN9YExJt2mBidL5JYh-VaTtXusp1m6Tzibc2tsE1qwtwZmUVzXRfJ-Dz4f5j8ZQuXx-fF_NlqnABu5QiBHNGeGkKSpUuVAaxxVAjDgvLtZaFyVCpc8JKTQ2RHA95FJOWoCGAkXgC7na-bV_WRivTdEFWYvihlmEjvHTi_6RxX2Ll14JxRkjGBoPrvUHwP72JnajdkKqqZGN8H0WWc04IxMVWOttJByIxBmMPZxAUW-xih13ssQ8LV8fPHeR_kPEv5pOBVQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2488550397</pqid></control><display><type>article</type><title>Sperm microRNAs confer depression susceptibility to offspring</title><source>Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wang, Yanbo ; Chen, Zhang-Peng ; Hu, Huanhuan ; Lei, Jieqiong ; Zhou, Zhen ; Yao, Bing ; Chen, Li ; Liang, Gaoli ; Zhan, Shoubin ; Zhu, Xiaoju ; Jin, Fangfang ; Ma, Rujun ; Zhang, Jun ; Liang, Hongwei ; Xing, Ming ; Chen, Xiao-Rui ; Zhang, Chen-Yu ; Zhu, Jing-Ning ; Chen, Xi</creator><creatorcontrib>Wang, Yanbo ; Chen, Zhang-Peng ; Hu, Huanhuan ; Lei, Jieqiong ; Zhou, Zhen ; Yao, Bing ; Chen, Li ; Liang, Gaoli ; Zhan, Shoubin ; Zhu, Xiaoju ; Jin, Fangfang ; Ma, Rujun ; Zhang, Jun ; Liang, Hongwei ; Xing, Ming ; Chen, Xiao-Rui ; Zhang, Chen-Yu ; Zhu, Jing-Ning ; Chen, Xi</creatorcontrib><description>Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.abd7605</identifier><identifier>PMID: 33568480</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Molecular Biology ; Neuroscience ; SciAdv r-articles</subject><ispartof>Science advances, 2021-02, Vol.7 (7)</ispartof><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</rights><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2021 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-61104758be966cd9c203f30d1809f8dda9e21bd457bd6e5a83760c7af51254ea3</citedby><cites>FETCH-LOGICAL-c390t-61104758be966cd9c203f30d1809f8dda9e21bd457bd6e5a83760c7af51254ea3</cites><orcidid>0000-0002-0992-0159 ; 0000-0002-2255-1423 ; 0000-0002-7630-8162 ; 0000-0003-0279-6535 ; 0000-0002-7471-6218 ; 0000-0002-6187-8576 ; 0000-0003-0529-993X ; 0000-0002-4528-9579 ; 0000-0001-7329-4386 ; 0000-0002-2942-7257 ; 0000-0002-1075-3255 ; 0000-0002-3695-9200 ; 0000-0003-0121-0029 ; 0000-0002-5807-4219 ; 0000-0002-8055-1544 ; 0000-0001-7252-0871 ; 0000-0001-9734-6654 ; 0000-0002-8502-2051 ; 0000-0002-3259-1488</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875527/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875527/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33568480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yanbo</creatorcontrib><creatorcontrib>Chen, Zhang-Peng</creatorcontrib><creatorcontrib>Hu, Huanhuan</creatorcontrib><creatorcontrib>Lei, Jieqiong</creatorcontrib><creatorcontrib>Zhou, Zhen</creatorcontrib><creatorcontrib>Yao, Bing</creatorcontrib><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Liang, Gaoli</creatorcontrib><creatorcontrib>Zhan, Shoubin</creatorcontrib><creatorcontrib>Zhu, Xiaoju</creatorcontrib><creatorcontrib>Jin, Fangfang</creatorcontrib><creatorcontrib>Ma, Rujun</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Liang, Hongwei</creatorcontrib><creatorcontrib>Xing, Ming</creatorcontrib><creatorcontrib>Chen, Xiao-Rui</creatorcontrib><creatorcontrib>Zhang, Chen-Yu</creatorcontrib><creatorcontrib>Zhu, Jing-Ning</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><title>Sperm microRNAs confer depression susceptibility to offspring</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression.</description><subject>Molecular Biology</subject><subject>Neuroscience</subject><subject>SciAdv r-articles</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkElrwzAQhUVpaUKaa4_Fx16cSpa1-NBCCN0gtNDlLGQtqYptuZIdyL-vQ9KQnmZg3ryZ9wFwieAMoYzeROWkXs9kqRmF5ASMM8xImpGcnx71IzCN8RtCiHJKCSrOwQhjQnnO4Rjcvrcm1EntVPBvL_OYKN9YExJt2mBidL5JYh-VaTtXusp1m6Tzibc2tsE1qwtwZmUVzXRfJ-Dz4f5j8ZQuXx-fF_NlqnABu5QiBHNGeGkKSpUuVAaxxVAjDgvLtZaFyVCpc8JKTQ2RHA95FJOWoCGAkXgC7na-bV_WRivTdEFWYvihlmEjvHTi_6RxX2Ll14JxRkjGBoPrvUHwP72JnajdkKqqZGN8H0WWc04IxMVWOttJByIxBmMPZxAUW-xih13ssQ8LV8fPHeR_kPEv5pOBVQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Wang, Yanbo</creator><creator>Chen, Zhang-Peng</creator><creator>Hu, Huanhuan</creator><creator>Lei, Jieqiong</creator><creator>Zhou, Zhen</creator><creator>Yao, Bing</creator><creator>Chen, Li</creator><creator>Liang, Gaoli</creator><creator>Zhan, Shoubin</creator><creator>Zhu, Xiaoju</creator><creator>Jin, Fangfang</creator><creator>Ma, Rujun</creator><creator>Zhang, Jun</creator><creator>Liang, Hongwei</creator><creator>Xing, Ming</creator><creator>Chen, Xiao-Rui</creator><creator>Zhang, Chen-Yu</creator><creator>Zhu, Jing-Ning</creator><creator>Chen, Xi</creator><general>American Association for the Advancement of Science</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0992-0159</orcidid><orcidid>https://orcid.org/0000-0002-2255-1423</orcidid><orcidid>https://orcid.org/0000-0002-7630-8162</orcidid><orcidid>https://orcid.org/0000-0003-0279-6535</orcidid><orcidid>https://orcid.org/0000-0002-7471-6218</orcidid><orcidid>https://orcid.org/0000-0002-6187-8576</orcidid><orcidid>https://orcid.org/0000-0003-0529-993X</orcidid><orcidid>https://orcid.org/0000-0002-4528-9579</orcidid><orcidid>https://orcid.org/0000-0001-7329-4386</orcidid><orcidid>https://orcid.org/0000-0002-2942-7257</orcidid><orcidid>https://orcid.org/0000-0002-1075-3255</orcidid><orcidid>https://orcid.org/0000-0002-3695-9200</orcidid><orcidid>https://orcid.org/0000-0003-0121-0029</orcidid><orcidid>https://orcid.org/0000-0002-5807-4219</orcidid><orcidid>https://orcid.org/0000-0002-8055-1544</orcidid><orcidid>https://orcid.org/0000-0001-7252-0871</orcidid><orcidid>https://orcid.org/0000-0001-9734-6654</orcidid><orcidid>https://orcid.org/0000-0002-8502-2051</orcidid><orcidid>https://orcid.org/0000-0002-3259-1488</orcidid></search><sort><creationdate>20210201</creationdate><title>Sperm microRNAs confer depression susceptibility to offspring</title><author>Wang, Yanbo ; Chen, Zhang-Peng ; Hu, Huanhuan ; Lei, Jieqiong ; Zhou, Zhen ; Yao, Bing ; Chen, Li ; Liang, Gaoli ; Zhan, Shoubin ; Zhu, Xiaoju ; Jin, Fangfang ; Ma, Rujun ; Zhang, Jun ; Liang, Hongwei ; Xing, Ming ; Chen, Xiao-Rui ; Zhang, Chen-Yu ; Zhu, Jing-Ning ; Chen, Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-61104758be966cd9c203f30d1809f8dda9e21bd457bd6e5a83760c7af51254ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Molecular Biology</topic><topic>Neuroscience</topic><topic>SciAdv r-articles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yanbo</creatorcontrib><creatorcontrib>Chen, Zhang-Peng</creatorcontrib><creatorcontrib>Hu, Huanhuan</creatorcontrib><creatorcontrib>Lei, Jieqiong</creatorcontrib><creatorcontrib>Zhou, Zhen</creatorcontrib><creatorcontrib>Yao, Bing</creatorcontrib><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Liang, Gaoli</creatorcontrib><creatorcontrib>Zhan, Shoubin</creatorcontrib><creatorcontrib>Zhu, Xiaoju</creatorcontrib><creatorcontrib>Jin, Fangfang</creatorcontrib><creatorcontrib>Ma, Rujun</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Liang, Hongwei</creatorcontrib><creatorcontrib>Xing, Ming</creatorcontrib><creatorcontrib>Chen, Xiao-Rui</creatorcontrib><creatorcontrib>Zhang, Chen-Yu</creatorcontrib><creatorcontrib>Zhu, Jing-Ning</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yanbo</au><au>Chen, Zhang-Peng</au><au>Hu, Huanhuan</au><au>Lei, Jieqiong</au><au>Zhou, Zhen</au><au>Yao, Bing</au><au>Chen, Li</au><au>Liang, Gaoli</au><au>Zhan, Shoubin</au><au>Zhu, Xiaoju</au><au>Jin, Fangfang</au><au>Ma, Rujun</au><au>Zhang, Jun</au><au>Liang, Hongwei</au><au>Xing, Ming</au><au>Chen, Xiao-Rui</au><au>Zhang, Chen-Yu</au><au>Zhu, Jing-Ning</au><au>Chen, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sperm microRNAs confer depression susceptibility to offspring</atitle><jtitle>Science advances</jtitle><addtitle>Sci Adv</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>7</volume><issue>7</issue><issn>2375-2548</issn><eissn>2375-2548</eissn><abstract>Evidence that offspring traits can be shaped by parental life experiences in an epigenetically inherited manner paves a way for understanding the etiology of depression. Here, we show that F1 offspring born to F0 males of depression-like model are susceptible to depression-like symptoms at the molecular, neuronal, and behavioral levels. Sperm small RNAs, and microRNAs (miRNAs) in particular, exhibit distinct expression profiles in F0 males of depression-like model and recapitulate paternal depressive-like phenotypes in F1 offspring. Neutralization of the abnormal miRNAs in zygotes by antisense strands rescues the acquired depressive-like phenotypes in F1 offspring born to F0 males of depression-like model. Mechanistically, sperm miRNAs reshape early embryonic transcriptional profiles in the core neuronal circuits toward depression-like phenotypes. Overall, the findings reveal a causal role of sperm miRNAs in the inheritance of depression and provide insight into the mechanism underlying susceptibility to depression.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>33568480</pmid><doi>10.1126/sciadv.abd7605</doi><orcidid>https://orcid.org/0000-0002-0992-0159</orcidid><orcidid>https://orcid.org/0000-0002-2255-1423</orcidid><orcidid>https://orcid.org/0000-0002-7630-8162</orcidid><orcidid>https://orcid.org/0000-0003-0279-6535</orcidid><orcidid>https://orcid.org/0000-0002-7471-6218</orcidid><orcidid>https://orcid.org/0000-0002-6187-8576</orcidid><orcidid>https://orcid.org/0000-0003-0529-993X</orcidid><orcidid>https://orcid.org/0000-0002-4528-9579</orcidid><orcidid>https://orcid.org/0000-0001-7329-4386</orcidid><orcidid>https://orcid.org/0000-0002-2942-7257</orcidid><orcidid>https://orcid.org/0000-0002-1075-3255</orcidid><orcidid>https://orcid.org/0000-0002-3695-9200</orcidid><orcidid>https://orcid.org/0000-0003-0121-0029</orcidid><orcidid>https://orcid.org/0000-0002-5807-4219</orcidid><orcidid>https://orcid.org/0000-0002-8055-1544</orcidid><orcidid>https://orcid.org/0000-0001-7252-0871</orcidid><orcidid>https://orcid.org/0000-0001-9734-6654</orcidid><orcidid>https://orcid.org/0000-0002-8502-2051</orcidid><orcidid>https://orcid.org/0000-0002-3259-1488</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2375-2548 |
| ispartof | Science advances, 2021-02, Vol.7 (7) |
| issn | 2375-2548 2375-2548 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7875527 |
| source | Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Molecular Biology Neuroscience SciAdv r-articles |
| title | Sperm microRNAs confer depression susceptibility to offspring |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T17%3A51%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sperm%20microRNAs%20confer%20depression%20susceptibility%20to%20offspring&rft.jtitle=Science%20advances&rft.au=Wang,%20Yanbo&rft.date=2021-02-01&rft.volume=7&rft.issue=7&rft.issn=2375-2548&rft.eissn=2375-2548&rft_id=info:doi/10.1126/sciadv.abd7605&rft_dat=%3Cproquest_pubme%3E2488550397%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2488550397&rft_id=info:pmid/33568480&rfr_iscdi=true |