Prevention of Anastomotic Leak Via Local Application of Tranexamic Acid to Target Bacterial-mediated Plasminogen Activation: A Practical Solution to a Complex Problem

OBJECTIVE:To investigate the role of bacterial- mediated plasminogen (PLG) activation in the pathogenesis of anastomotic leak (AL) and its mitigation by tranexamic acid (TXA). BACKGROUND:AL is the most feared complication of colorectal resections. The pathobiology of AL in the setting of a technical...

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Veröffentlicht in:	Annals of surgery 2021-12, Vol.274 (6), p.e1038-e1046
Hauptverfasser:	Jacobson, Richard A., Williamson, Ashley J., Wienholts, Kiedo, Gaines, Sara, Hyoju, Sanjiv, van Goor, Harry, Zaborin, Alexander, Shogan, Benjamin D., Zaborina, Olga, Alverdy, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anastomotic Leak - microbiology Anastomotic Leak - prevention & control Animals Collagen - drug effects Colon - surgery Disease Models, Animal Enema Enterococcus faecalis Mice Mice, Inbred C57BL Microscopy, Confocal Plasminogen - metabolism Pseudomonas aeruginosa Tranexamic Acid - administration & dosage
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