SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study
ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including...
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| Veröffentlicht in: | Gut 2021-06, Vol.70 (6), p.1061-1069 |
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| creator | Pandanaboyana, Sanjay Moir, John Leeds, John S Oppong, Kofi Kanwar, Aditya Marzouk, Ahmed Belgaumkar, Ajay Gupta, Ajay Siriwardena, Ajith K Haque, Ali Raza Awan, Altaf Balakrishnan, Anita Rawashdeh, Arab Ivanov, Bogdan Parmar, Chetan M Halloran, Christopher Caruana, Clifford Borg, Cynthia-Michelle Gomez, Dhanny Damaskos, Dimitrios Karavias, Dimitrios Finch, Guy Ebied, Husam K Pine, James R A Skipworth, James Milburn, James Latif, Javed Ratnam Apollos, Jeyakumar El Kafsi, Jihène Windsor, John A Roberts, Keith Wang, Kelvin Ravi, Krish V Coats, Maria Hollyman, Marianne Phillips, Mary Okocha, Michael SJ Wilson, Michael A Ameer, Nadeem Kumar, Nagappan Shah, Nehal Lapolla, Pierfrancesco Magee, Connor Al-Sarireh, Bilal Lunevicius, Raimundas Benhmida, Rami Singhal, Rishi Balachandra, Srinivasan Demirli Atıcı, Semra Jaunoo, Shameen Dwerryhouse, Simon Boyce, Tamsin Charalampakis, Vasileios Kanakala, Venkat Abbas, Zaigham Nayar, Manu |
| description | ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p |
| doi_str_mv | 10.1136/gutjnl-2020-323364 |
| format | Article |
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This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.ConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.]]></description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2020-323364</identifier><identifier>PMID: 33547182</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Clinical outcomes ; Cohort Studies ; Collaboration ; Comorbidity ; Covid-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; Cysts ; Disease Progression ; Etiology ; Female ; Fever ; Humans ; Infections ; Intensive Care Units - statistics & numerical data ; International Cooperation ; Length of stay ; Length of Stay - statistics & numerical data ; Male ; Middle Aged ; Mortality ; Organ Dysfunction Scores ; Outcome Assessment, Health Care ; Pancreas ; Pancreatitis ; Pancreatitis - diagnosis ; Pancreatitis - mortality ; Pancreatitis - physiopathology ; Pandemics ; Patients ; Regression analysis ; Respiratory distress syndrome ; Respiratory Distress Syndrome - diagnosis ; Respiratory Distress Syndrome - etiology ; SARS-CoV-2 - isolation & purification ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index</subject><ispartof>Gut, 2021-06, Vol.70 (6), p.1061-1069</ispartof><rights>Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b468t-5604b85ce4a7bb54d29ff32215c100d1cc484a77831cf7d6b610aea710d1d93b3</citedby><cites>FETCH-LOGICAL-b468t-5604b85ce4a7bb54d29ff32215c100d1cc484a77831cf7d6b610aea710d1d93b3</cites><orcidid>0000-0003-3099-2197 ; 0000-0002-5140-6225 ; 0000-0002-1196-3406 ; 0000-0002-7381-7412 ; 0000-0002-3161-4713</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871229/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871229/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33547182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pandanaboyana, Sanjay</creatorcontrib><creatorcontrib>Moir, John</creatorcontrib><creatorcontrib>Leeds, John S</creatorcontrib><creatorcontrib>Oppong, Kofi</creatorcontrib><creatorcontrib>Kanwar, Aditya</creatorcontrib><creatorcontrib>Marzouk, Ahmed</creatorcontrib><creatorcontrib>Belgaumkar, Ajay</creatorcontrib><creatorcontrib>Gupta, Ajay</creatorcontrib><creatorcontrib>Siriwardena, Ajith K</creatorcontrib><creatorcontrib>Haque, Ali Raza</creatorcontrib><creatorcontrib>Awan, Altaf</creatorcontrib><creatorcontrib>Balakrishnan, Anita</creatorcontrib><creatorcontrib>Rawashdeh, Arab</creatorcontrib><creatorcontrib>Ivanov, Bogdan</creatorcontrib><creatorcontrib>Parmar, Chetan</creatorcontrib><creatorcontrib>M Halloran, Christopher</creatorcontrib><creatorcontrib>Caruana, Clifford</creatorcontrib><creatorcontrib>Borg, Cynthia-Michelle</creatorcontrib><creatorcontrib>Gomez, Dhanny</creatorcontrib><creatorcontrib>Damaskos, Dimitrios</creatorcontrib><creatorcontrib>Karavias, Dimitrios</creatorcontrib><creatorcontrib>Finch, Guy</creatorcontrib><creatorcontrib>Ebied, Husam</creatorcontrib><creatorcontrib>K Pine, James</creatorcontrib><creatorcontrib>R A Skipworth, James</creatorcontrib><creatorcontrib>Milburn, James</creatorcontrib><creatorcontrib>Latif, Javed</creatorcontrib><creatorcontrib>Ratnam Apollos, Jeyakumar</creatorcontrib><creatorcontrib>El Kafsi, Jihène</creatorcontrib><creatorcontrib>Windsor, John A</creatorcontrib><creatorcontrib>Roberts, Keith</creatorcontrib><creatorcontrib>Wang, Kelvin</creatorcontrib><creatorcontrib>Ravi, Krish</creatorcontrib><creatorcontrib>V Coats, Maria</creatorcontrib><creatorcontrib>Hollyman, Marianne</creatorcontrib><creatorcontrib>Phillips, Mary</creatorcontrib><creatorcontrib>Okocha, Michael</creatorcontrib><creatorcontrib>SJ Wilson, Michael</creatorcontrib><creatorcontrib>A Ameer, Nadeem</creatorcontrib><creatorcontrib>Kumar, Nagappan</creatorcontrib><creatorcontrib>Shah, Nehal</creatorcontrib><creatorcontrib>Lapolla, Pierfrancesco</creatorcontrib><creatorcontrib>Magee, Connor</creatorcontrib><creatorcontrib>Al-Sarireh, Bilal</creatorcontrib><creatorcontrib>Lunevicius, Raimundas</creatorcontrib><creatorcontrib>Benhmida, Rami</creatorcontrib><creatorcontrib>Singhal, Rishi</creatorcontrib><creatorcontrib>Balachandra, Srinivasan</creatorcontrib><creatorcontrib>Demirli Atıcı, Semra</creatorcontrib><creatorcontrib>Jaunoo, Shameen</creatorcontrib><creatorcontrib>Dwerryhouse, Simon</creatorcontrib><creatorcontrib>Boyce, Tamsin</creatorcontrib><creatorcontrib>Charalampakis, Vasileios</creatorcontrib><creatorcontrib>Kanakala, Venkat</creatorcontrib><creatorcontrib>Abbas, Zaigham</creatorcontrib><creatorcontrib>Nayar, Manu</creatorcontrib><creatorcontrib>COVID PAN collaborative group</creatorcontrib><title>SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study</title><title>Gut</title><addtitle>Gut</addtitle><description><![CDATA[ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.ConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.]]></description><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Collaboration</subject><subject>Comorbidity</subject><subject>Covid-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>Cysts</subject><subject>Disease Progression</subject><subject>Etiology</subject><subject>Female</subject><subject>Fever</subject><subject>Humans</subject><subject>Infections</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>International Cooperation</subject><subject>Length of stay</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Organ Dysfunction Scores</subject><subject>Outcome Assessment, Health Care</subject><subject>Pancreas</subject><subject>Pancreatitis</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - mortality</subject><subject>Pancreatitis - physiopathology</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome - diagnosis</subject><subject>Respiratory Distress Syndrome - etiology</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness 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infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study</title><author>Pandanaboyana, Sanjay ; Moir, John ; Leeds, John S ; Oppong, Kofi ; Kanwar, Aditya ; Marzouk, Ahmed ; Belgaumkar, Ajay ; Gupta, Ajay ; Siriwardena, Ajith K ; Haque, Ali Raza ; Awan, Altaf ; Balakrishnan, Anita ; Rawashdeh, Arab ; Ivanov, Bogdan ; Parmar, Chetan ; M Halloran, Christopher ; Caruana, Clifford ; Borg, Cynthia-Michelle ; Gomez, Dhanny ; Damaskos, Dimitrios ; Karavias, Dimitrios ; Finch, Guy ; Ebied, Husam ; K Pine, James ; R A Skipworth, James ; Milburn, James ; Latif, Javed ; Ratnam Apollos, Jeyakumar ; El Kafsi, Jihène ; Windsor, John A ; Roberts, Keith ; Wang, Kelvin ; Ravi, Krish ; V Coats, Maria ; Hollyman, Marianne ; Phillips, Mary ; Okocha, Michael ; SJ Wilson, Michael ; A Ameer, Nadeem ; Kumar, Nagappan ; Shah, Nehal ; Lapolla, Pierfrancesco ; Magee, Connor ; Al-Sarireh, Bilal ; Lunevicius, Raimundas ; Benhmida, Rami ; Singhal, Rishi ; Balachandra, Srinivasan ; Demirli Atıcı, Semra ; Jaunoo, Shameen ; Dwerryhouse, Simon ; Boyce, Tamsin ; Charalampakis, Vasileios ; Kanakala, Venkat ; Abbas, Zaigham ; Nayar, Manu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b468t-5604b85ce4a7bb54d29ff32215c100d1cc484a77831cf7d6b610aea710d1d93b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical outcomes</topic><topic>Cohort Studies</topic><topic>Collaboration</topic><topic>Comorbidity</topic><topic>Covid-19</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - epidemiology</topic><topic>Cysts</topic><topic>Disease Progression</topic><topic>Etiology</topic><topic>Female</topic><topic>Fever</topic><topic>Humans</topic><topic>Infections</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>International Cooperation</topic><topic>Length of stay</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Organ Dysfunction Scores</topic><topic>Outcome Assessment, Health Care</topic><topic>Pancreas</topic><topic>Pancreatitis</topic><topic>Pancreatitis - diagnosis</topic><topic>Pancreatitis - mortality</topic><topic>Pancreatitis - physiopathology</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome - diagnosis</topic><topic>Respiratory Distress Syndrome - etiology</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandanaboyana, Sanjay</creatorcontrib><creatorcontrib>Moir, John</creatorcontrib><creatorcontrib>Leeds, John S</creatorcontrib><creatorcontrib>Oppong, Kofi</creatorcontrib><creatorcontrib>Kanwar, Aditya</creatorcontrib><creatorcontrib>Marzouk, Ahmed</creatorcontrib><creatorcontrib>Belgaumkar, Ajay</creatorcontrib><creatorcontrib>Gupta, Ajay</creatorcontrib><creatorcontrib>Siriwardena, Ajith K</creatorcontrib><creatorcontrib>Haque, Ali Raza</creatorcontrib><creatorcontrib>Awan, Altaf</creatorcontrib><creatorcontrib>Balakrishnan, Anita</creatorcontrib><creatorcontrib>Rawashdeh, Arab</creatorcontrib><creatorcontrib>Ivanov, Bogdan</creatorcontrib><creatorcontrib>Parmar, Chetan</creatorcontrib><creatorcontrib>M Halloran, Christopher</creatorcontrib><creatorcontrib>Caruana, Clifford</creatorcontrib><creatorcontrib>Borg, Cynthia-Michelle</creatorcontrib><creatorcontrib>Gomez, Dhanny</creatorcontrib><creatorcontrib>Damaskos, Dimitrios</creatorcontrib><creatorcontrib>Karavias, Dimitrios</creatorcontrib><creatorcontrib>Finch, Guy</creatorcontrib><creatorcontrib>Ebied, Husam</creatorcontrib><creatorcontrib>K Pine, James</creatorcontrib><creatorcontrib>R A Skipworth, James</creatorcontrib><creatorcontrib>Milburn, James</creatorcontrib><creatorcontrib>Latif, Javed</creatorcontrib><creatorcontrib>Ratnam Apollos, Jeyakumar</creatorcontrib><creatorcontrib>El Kafsi, Jihène</creatorcontrib><creatorcontrib>Windsor, John A</creatorcontrib><creatorcontrib>Roberts, Keith</creatorcontrib><creatorcontrib>Wang, Kelvin</creatorcontrib><creatorcontrib>Ravi, Krish</creatorcontrib><creatorcontrib>V Coats, Maria</creatorcontrib><creatorcontrib>Hollyman, Marianne</creatorcontrib><creatorcontrib>Phillips, Mary</creatorcontrib><creatorcontrib>Okocha, Michael</creatorcontrib><creatorcontrib>SJ Wilson, Michael</creatorcontrib><creatorcontrib>A Ameer, Nadeem</creatorcontrib><creatorcontrib>Kumar, Nagappan</creatorcontrib><creatorcontrib>Shah, Nehal</creatorcontrib><creatorcontrib>Lapolla, Pierfrancesco</creatorcontrib><creatorcontrib>Magee, Connor</creatorcontrib><creatorcontrib>Al-Sarireh, Bilal</creatorcontrib><creatorcontrib>Lunevicius, Raimundas</creatorcontrib><creatorcontrib>Benhmida, Rami</creatorcontrib><creatorcontrib>Singhal, Rishi</creatorcontrib><creatorcontrib>Balachandra, Srinivasan</creatorcontrib><creatorcontrib>Demirli Atıcı, Semra</creatorcontrib><creatorcontrib>Jaunoo, Shameen</creatorcontrib><creatorcontrib>Dwerryhouse, Simon</creatorcontrib><creatorcontrib>Boyce, Tamsin</creatorcontrib><creatorcontrib>Charalampakis, Vasileios</creatorcontrib><creatorcontrib>Kanakala, Venkat</creatorcontrib><creatorcontrib>Abbas, Zaigham</creatorcontrib><creatorcontrib>Nayar, Manu</creatorcontrib><creatorcontrib>COVID PAN collaborative group</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandanaboyana, Sanjay</au><au>Moir, John</au><au>Leeds, John S</au><au>Oppong, Kofi</au><au>Kanwar, Aditya</au><au>Marzouk, Ahmed</au><au>Belgaumkar, Ajay</au><au>Gupta, Ajay</au><au>Siriwardena, Ajith K</au><au>Haque, Ali Raza</au><au>Awan, Altaf</au><au>Balakrishnan, Anita</au><au>Rawashdeh, Arab</au><au>Ivanov, Bogdan</au><au>Parmar, Chetan</au><au>M Halloran, Christopher</au><au>Caruana, Clifford</au><au>Borg, Cynthia-Michelle</au><au>Gomez, Dhanny</au><au>Damaskos, Dimitrios</au><au>Karavias, Dimitrios</au><au>Finch, Guy</au><au>Ebied, Husam</au><au>K Pine, James</au><au>R A Skipworth, James</au><au>Milburn, James</au><au>Latif, Javed</au><au>Ratnam Apollos, Jeyakumar</au><au>El Kafsi, Jihène</au><au>Windsor, John A</au><au>Roberts, Keith</au><au>Wang, Kelvin</au><au>Ravi, Krish</au><au>V Coats, Maria</au><au>Hollyman, Marianne</au><au>Phillips, Mary</au><au>Okocha, Michael</au><au>SJ Wilson, Michael</au><au>A Ameer, Nadeem</au><au>Kumar, Nagappan</au><au>Shah, Nehal</au><au>Lapolla, Pierfrancesco</au><au>Magee, Connor</au><au>Al-Sarireh, Bilal</au><au>Lunevicius, Raimundas</au><au>Benhmida, Rami</au><au>Singhal, Rishi</au><au>Balachandra, Srinivasan</au><au>Demirli Atıcı, Semra</au><au>Jaunoo, Shameen</au><au>Dwerryhouse, Simon</au><au>Boyce, Tamsin</au><au>Charalampakis, Vasileios</au><au>Kanakala, Venkat</au><au>Abbas, Zaigham</au><au>Nayar, Manu</au><aucorp>COVID PAN collaborative group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>70</volume><issue>6</issue><spage>1061</spage><epage>1069</epage><pages>1061-1069</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><abstract><![CDATA[ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.ConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.]]></abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>33547182</pmid><doi>10.1136/gutjnl-2020-323364</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3099-2197</orcidid><orcidid>https://orcid.org/0000-0002-5140-6225</orcidid><orcidid>https://orcid.org/0000-0002-1196-3406</orcidid><orcidid>https://orcid.org/0000-0002-7381-7412</orcidid><orcidid>https://orcid.org/0000-0002-3161-4713</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0017-5749 |
| ispartof | Gut, 2021-06, Vol.70 (6), p.1061-1069 |
| issn | 0017-5749 1468-3288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7871229 |
| source | MEDLINE; PubMed Central |
| subjects | Clinical outcomes Cohort Studies Collaboration Comorbidity Covid-19 COVID-19 - diagnosis COVID-19 - epidemiology Cysts Disease Progression Etiology Female Fever Humans Infections Intensive Care Units - statistics & numerical data International Cooperation Length of stay Length of Stay - statistics & numerical data Male Middle Aged Mortality Organ Dysfunction Scores Outcome Assessment, Health Care Pancreas Pancreatitis Pancreatitis - diagnosis Pancreatitis - mortality Pancreatitis - physiopathology Pandemics Patients Regression analysis Respiratory distress syndrome Respiratory Distress Syndrome - diagnosis Respiratory Distress Syndrome - etiology SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index |
| title | SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study |
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