An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins

[Display omitted] •In the presence of IP6 arrestin-2 and arrestin-3 form different oligomers.•IP6 activates arrestin-3, but does not activate arrestin-2.•An eight-residue insertion in arrestin-2 controls differential oligomerization. G protein coupled receptors signal through G proteins or arrestins...

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