The role of cap-dependent translation in aged-related changes in neuroimmunity and affective behaviors

Translation regulation in the context of aged-associated inflammation and behavioral impairments is not well characterized. Aged individuals experience lower life quality due to behavioral impairments. In this study, we used young and aged transgenic mice that are unable to activate the cap-binding...

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Veröffentlicht in:	Neurobiology of aging 2021-02, Vol.98, p.173-184
Hauptverfasser:	Mody, Prapti H., Lucia dos Santos, Natalia, Lenert, Melissa E., Barron, Luz R., Nottingham, Bethany A., Burton, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affect Aging Aging - immunology Aging - metabolism Aging - psychology Animals Anxiety Anxiety - genetics Brain - metabolism Cognition Cytokines - metabolism Depression Depression - genetics eIF4E Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - metabolism Inflammation Inflammation - genetics Inflammation Mediators - metabolism Mice, Transgenic Phosphorylation Protein Biosynthesis - genetics Protein Biosynthesis - physiology RNA Cap-Binding Proteins - metabolism
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