A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking
Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to m...
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| Veröffentlicht in: | Biomaterials 2021-02, Vol.269, p.120630-120630, Article 120630 |
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| creator | Harmsen, Stefan Medine, Emin Ilker Moroz, Maxim Nurili, Fuad Lobo, Jose Dong, Yiyu Turkekul, Mezruh Pillarsetty, Naga Vara Kishore Ting, Richard Ponomarev, Vladimir Akin, Oguz Aras, Omer |
| description | Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodistribution and fate following infusion. To this end, we developed a dual-modal PET/near infrared fluorescent (NIRF) nanoparticle-based imaging agent for non-genomic labeling of human CAR T cells. Since the PET/NIRF nanoparticles did not affect cell viability or cytotoxic functionality and enabled long-term whole-body CAR T cell tracking using PET and NIRF in an ovarian peritoneal carcinomatosis model, this platform is a viable imaging technology to be applied in other cancer models. |
| doi_str_mv | 10.1016/j.biomaterials.2020.120630 |
| format | Article |
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The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodistribution and fate following infusion. To this end, we developed a dual-modal PET/near infrared fluorescent (NIRF) nanoparticle-based imaging agent for non-genomic labeling of human CAR T cells. Since the PET/NIRF nanoparticles did not affect cell viability or cytotoxic functionality and enabled long-term whole-body CAR T cell tracking using PET and NIRF in an ovarian peritoneal carcinomatosis model, this platform is a viable imaging technology to be applied in other cancer models.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2020.120630</identifier><identifier>PMID: 33395580</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Cell Line, Tumor ; Cell Tracking ; Dual-modal ; Humans ; Immune cell labeling ; Immunotherapy, Adoptive ; Nanomedicine ; Near-infrared fluorescence ; PET ; Positron-Emission Tomography ; Tissue Distribution ; Tracking</subject><ispartof>Biomaterials, 2021-02, Vol.269, p.120630-120630, Article 120630</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. 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Medine, Emin Ilker ; Moroz, Maxim ; Nurili, Fuad ; Lobo, Jose ; Dong, Yiyu ; Turkekul, Mezruh ; Pillarsetty, Naga Vara Kishore ; Ting, Richard ; Ponomarev, Vladimir ; Akin, Oguz ; Aras, Omer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-b1e86d3209bf8d53d7dbaf2e26d1c444b8052a88e610afe928da9bbc4157bb623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cell Line, Tumor</topic><topic>Cell Tracking</topic><topic>Dual-modal</topic><topic>Humans</topic><topic>Immune cell labeling</topic><topic>Immunotherapy, Adoptive</topic><topic>Nanomedicine</topic><topic>Near-infrared fluorescence</topic><topic>PET</topic><topic>Positron-Emission Tomography</topic><topic>Tissue Distribution</topic><topic>Tracking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harmsen, Stefan</creatorcontrib><creatorcontrib>Medine, Emin Ilker</creatorcontrib><creatorcontrib>Moroz, Maxim</creatorcontrib><creatorcontrib>Nurili, Fuad</creatorcontrib><creatorcontrib>Lobo, Jose</creatorcontrib><creatorcontrib>Dong, Yiyu</creatorcontrib><creatorcontrib>Turkekul, Mezruh</creatorcontrib><creatorcontrib>Pillarsetty, Naga Vara Kishore</creatorcontrib><creatorcontrib>Ting, Richard</creatorcontrib><creatorcontrib>Ponomarev, Vladimir</creatorcontrib><creatorcontrib>Akin, Oguz</creatorcontrib><creatorcontrib>Aras, Omer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harmsen, Stefan</au><au>Medine, Emin Ilker</au><au>Moroz, Maxim</au><au>Nurili, Fuad</au><au>Lobo, Jose</au><au>Dong, Yiyu</au><au>Turkekul, Mezruh</au><au>Pillarsetty, Naga Vara Kishore</au><au>Ting, Richard</au><au>Ponomarev, Vladimir</au><au>Akin, Oguz</au><au>Aras, Omer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>269</volume><spage>120630</spage><epage>120630</epage><pages>120630-120630</pages><artnum>120630</artnum><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodistribution and fate following infusion. To this end, we developed a dual-modal PET/near infrared fluorescent (NIRF) nanoparticle-based imaging agent for non-genomic labeling of human CAR T cells. Since the PET/NIRF nanoparticles did not affect cell viability or cytotoxic functionality and enabled long-term whole-body CAR T cell tracking using PET and NIRF in an ovarian peritoneal carcinomatosis model, this platform is a viable imaging technology to be applied in other cancer models.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33395580</pmid><doi>10.1016/j.biomaterials.2020.120630</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9119-9128</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cell Line, Tumor Cell Tracking Dual-modal Humans Immune cell labeling Immunotherapy, Adoptive Nanomedicine Near-infrared fluorescence PET Positron-Emission Tomography Tissue Distribution Tracking |
| title | A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking |
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