Blood Urea Nitrogen and In-Hospital Mortality in Critically Ill Patients with Cardiogenic Shock: Analysis of the MIMIC-III Database
The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort...
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| description | The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort study, in which data were obtained from the Medical Information Mart for Intensive Care III V1.4 database. Data from 697 patients with CS were analyzed. Logistic regression and subgroup analyses were used to assess the association between BUN and hospital mortality in patients with CS. The average age of the 697 participants was 71.14 years, and approximately 42.18% were men. In the multivariate logistic regression model, after adjusting for age, sex, diabetes, cardiac arrhythmias, urine output, simplified acute physiology score II, sequential organ failure assessment, creatinine, anion gap, and heart rate, high BUN demonstrated strong associations with increased in-hospital mortality (per standard deviation increase: odds ratio [OR] 1.47, 95% confidence interval [CI] 1.13–1.92). A similar result was observed in BUN tertile groups (BUN 23–37 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.42 [0.86–2.34]; BUN 38–165 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.99 [1.10–3.62]; P trend 0.0272). Subgroup analysis did not reveal any significant interactions among various subgroups, and higher BUN was associated with adverse clinical outcomes in patients with CS. |
| doi_str_mv | 10.1155/2021/5948636 |
| format | Article |
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Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort study, in which data were obtained from the Medical Information Mart for Intensive Care III V1.4 database. Data from 697 patients with CS were analyzed. Logistic regression and subgroup analyses were used to assess the association between BUN and hospital mortality in patients with CS. The average age of the 697 participants was 71.14 years, and approximately 42.18% were men. In the multivariate logistic regression model, after adjusting for age, sex, diabetes, cardiac arrhythmias, urine output, simplified acute physiology score II, sequential organ failure assessment, creatinine, anion gap, and heart rate, high BUN demonstrated strong associations with increased in-hospital mortality (per standard deviation increase: odds ratio [OR] 1.47, 95% confidence interval [CI] 1.13–1.92). A similar result was observed in BUN tertile groups (BUN 23–37 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.42 [0.86–2.34]; BUN 38–165 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.99 [1.10–3.62]; P trend 0.0272). Subgroup analysis did not reveal any significant interactions among various subgroups, and higher BUN was associated with adverse clinical outcomes in patients with CS.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/5948636</identifier><identifier>PMID: 33604376</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Age ; Biomedical research ; Blood ; Blood platelets ; Blood pressure ; Cardiac arrhythmia ; Confidence intervals ; Creatinine ; Diabetes ; Diabetes mellitus ; Disease ; Ethnicity ; Glucose ; Heart attacks ; Heart failure ; Heart rate ; Hemoglobin ; Hospitals ; Hypertension ; Intensive care ; Laboratories ; Mortality ; Nitrogen ; Patients ; Physiology ; Potassium ; Regression analysis ; Regression models ; Renal replacement therapy ; Statistical analysis ; Structured Query Language-SQL ; Subgroups ; Urea ; Ureas ; Urine ; Variables</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.5948636-5948636</ispartof><rights>Copyright © 2021 En-qian Liu and Chun-lai Zeng.</rights><rights>Copyright © 2021 En-qian Liu and Chun-lai Zeng. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 En-qian Liu and Chun-lai Zeng. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-b6c94935f9720953925735e35abc4e7d482ff3a4fca10868129a1324aff06f23</citedby><cites>FETCH-LOGICAL-c448t-b6c94935f9720953925735e35abc4e7d482ff3a4fca10868129a1324aff06f23</cites><orcidid>0000-0002-1611-8965 ; 0000-0001-5674-1447</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33604376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chiew, Yeong Shiong</contributor><contributor>Yeong Shiong Chiew</contributor><creatorcontrib>Liu, En-qian</creatorcontrib><creatorcontrib>Zeng, Chun-lai</creatorcontrib><title>Blood Urea Nitrogen and In-Hospital Mortality in Critically Ill Patients with Cardiogenic Shock: Analysis of the MIMIC-III Database</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort study, in which data were obtained from the Medical Information Mart for Intensive Care III V1.4 database. Data from 697 patients with CS were analyzed. Logistic regression and subgroup analyses were used to assess the association between BUN and hospital mortality in patients with CS. The average age of the 697 participants was 71.14 years, and approximately 42.18% were men. In the multivariate logistic regression model, after adjusting for age, sex, diabetes, cardiac arrhythmias, urine output, simplified acute physiology score II, sequential organ failure assessment, creatinine, anion gap, and heart rate, high BUN demonstrated strong associations with increased in-hospital mortality (per standard deviation increase: odds ratio [OR] 1.47, 95% confidence interval [CI] 1.13–1.92). A similar result was observed in BUN tertile groups (BUN 23–37 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.42 [0.86–2.34]; BUN 38–165 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.99 [1.10–3.62]; P trend 0.0272). Subgroup analysis did not reveal any significant interactions among various subgroups, and higher BUN was associated with adverse clinical outcomes in patients with CS.</description><subject>Age</subject><subject>Biomedical research</subject><subject>Blood</subject><subject>Blood platelets</subject><subject>Blood pressure</subject><subject>Cardiac arrhythmia</subject><subject>Confidence intervals</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease</subject><subject>Ethnicity</subject><subject>Glucose</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Intensive care</subject><subject>Laboratories</subject><subject>Mortality</subject><subject>Nitrogen</subject><subject>Patients</subject><subject>Physiology</subject><subject>Potassium</subject><subject>Regression 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, En-qian</au><au>Zeng, Chun-lai</au><au>Chiew, Yeong Shiong</au><au>Yeong Shiong Chiew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood Urea Nitrogen and In-Hospital Mortality in Critically Ill Patients with Cardiogenic Shock: Analysis of the MIMIC-III Database</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>5948636</spage><epage>5948636</epage><pages>5948636-5948636</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort study, in which data were obtained from the Medical Information Mart for Intensive Care III V1.4 database. Data from 697 patients with CS were analyzed. Logistic regression and subgroup analyses were used to assess the association between BUN and hospital mortality in patients with CS. The average age of the 697 participants was 71.14 years, and approximately 42.18% were men. In the multivariate logistic regression model, after adjusting for age, sex, diabetes, cardiac arrhythmias, urine output, simplified acute physiology score II, sequential organ failure assessment, creatinine, anion gap, and heart rate, high BUN demonstrated strong associations with increased in-hospital mortality (per standard deviation increase: odds ratio [OR] 1.47, 95% confidence interval [CI] 1.13–1.92). A similar result was observed in BUN tertile groups (BUN 23–37 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.42 [0.86–2.34]; BUN 38–165 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.99 [1.10–3.62]; P trend 0.0272). Subgroup analysis did not reveal any significant interactions among various subgroups, and higher BUN was associated with adverse clinical outcomes in patients with CS.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>33604376</pmid><doi>10.1155/2021/5948636</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1611-8965</orcidid><orcidid>https://orcid.org/0000-0001-5674-1447</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Biomedical research Blood Blood platelets Blood pressure Cardiac arrhythmia Confidence intervals Creatinine Diabetes Diabetes mellitus Disease Ethnicity Glucose Heart attacks Heart failure Heart rate Hemoglobin Hospitals Hypertension Intensive care Laboratories Mortality Nitrogen Patients Physiology Potassium Regression analysis Regression models Renal replacement therapy Statistical analysis Structured Query Language-SQL Subgroups Urea Ureas Urine Variables |
| title | Blood Urea Nitrogen and In-Hospital Mortality in Critically Ill Patients with Cardiogenic Shock: Analysis of the MIMIC-III Database |
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