Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model

Abstract Background Methionyl-tRNA synthetase (MetRS) inhibitors are under investigation for the treatment of intestinal infections caused by Giardia lamblia. Objectives To properly analyse the therapeutic potential of the MetRS inhibitor 1717, experimental tools including a robust cell-based assay...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2020-05, Vol.75 (5), p.1218-1227
Hauptverfasser:	Michaels, Samantha A, Shih, Han-Wei, Zhang, Bailin, Navaluna, Edelmar D, Zhang, Zhongsheng, Ranade, Ranae M, Gillespie, J Robert, Merritt, Ethan A, Fan, Erkang, Buckner, Frederick S, Paredez, Alexander R, Ojo, Kayode K
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Research
Online-Zugang:	Volltext
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