G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (...

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Veröffentlicht in:	Cell 2021-02, Vol.184 (3), p.655-674.e27
Hauptverfasser:	Prentzell, Mirja Tamara, Rehbein, Ulrike, Cadena Sandoval, Marti, De Meulemeester, Ann-Sofie, Baumeister, Ralf, Brohée, Laura, Berdel, Bianca, Bockwoldt, Mathias, Carroll, Bernadette, Chowdhury, Suvagata Roy, von Deimling, Andreas, Demetriades, Constantinos, Figlia, Gianluca, de Araujo, Mariana Eca Guimaraes, Heberle, Alexander M., Heiland, Ines, Holzwarth, Birgit, Huber, Lukas A., Jaworski, Jacek, Kedra, Magdalena, Kern, Katharina, Kopach, Andrii, Korolchuk, Viktor I., van 't Land-Kuper, Ineke, Macias, Matylda, Nellist, Mark, Palm, Wilhelm, Pusch, Stefan, Ramos Pittol, Jose Miguel, Reil, Michèle, Reintjes, Anja, Reuter, Friederike, Sampson, Julian R., Scheldeman, Chloë, Siekierska, Aleksandra, Stefan, Eduard, Teleman, Aurelio A., Thomas, Laura E., Torres-Quesada, Omar, Trump, Saskia, West, Hannah D., de Witte, Peter, Woltering, Sandra, Yordanov, Teodor E., Zmorzynska, Justyna, Opitz, Christiane A., Thedieck, Kathrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Breast Neoplasms - metabolism Breast Neoplasms - pathology cancer Cell Line, Tumor Cell Movement - drug effects Cytoplasmic Granules - drug effects Cytoplasmic Granules - metabolism DNA Helicases - chemistry DNA Helicases - metabolism Evolution, Molecular Female G3BP1 G3BP2 Humans Insulin - pharmacology Lysosomal Membrane Proteins - metabolism lysosome Lysosomes - drug effects Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 - metabolism Medical disciplines: 700 Medical molecular biology: 711 Medisinsk molekylærbiologi: 711 Medisinske Fag: 700 metabolism mTORC1 neuronal function Neurons - drug effects Neurons - metabolism Phenotype Poly-ADP-Ribose Binding Proteins - chemistry Poly-ADP-Ribose Binding Proteins - metabolism Rats Rats, Wistar RNA Helicases - chemistry RNA Helicases - metabolism RNA Recognition Motif Proteins - chemistry RNA Recognition Motif Proteins - metabolism RNA-Binding Proteins - metabolism Signal Transduction - drug effects stress granule TSC complex Tuberous Sclerosis - metabolism VDP Zebrafish - metabolism
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