VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk

It is well established that a subset of cells within primary breast cancers can undergo an epithelial-to-mesenchymal transition (EMT), although the role of EMT in metastasis remains controversial. We previously demonstrated that breast cancer cells that had undergone an oncogenic EMT could increase...

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Veröffentlicht in:	Oncogene 2021-02, Vol.40 (5), p.964-979
Hauptverfasser:	Kong, Deguang, Zhou, Hengbo, Neelakantan, Deepika, Hughes, Connor J., Hsu, Jessica Y., Srinivasan, Ramakrishnan Rajaram, Lewis, Michael T., Ford, Heide L.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/21 13/89 59/5 631/67/1347 631/67/322 631/80/304 64/60 82/29 82/80 96/109 Apoptosis Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Care and treatment Cell activation Cell Biology Cell Line, Tumor Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Development and progression Epithelial-Mesenchymal Transition - genetics Female Gene expression Gene Expression Regulation, Neoplastic - genetics Genetic aspects Health aspects Hedgehog protein Hedgehog Proteins - genetics Homeodomain Proteins - genetics Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Neoplasm Metastasis Neuropilin-2 - genetics Oncology Paracrine signalling Phenotypes Signal Transduction - genetics Tumor cells Vascular endothelial growth factor Vascular Endothelial Growth Factor C - genetics
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