Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells

High-risk (HR) human papillomaviruses are known causative agents in 5% of human cancers including cervical, ano-genital and head and neck carcinomas. In part, HR-HPV causes cancer by targeting host-cell tumor suppressors including retinoblastoma protein (pRb) and RB-like proteins p107 and p130. HR-H...

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Veröffentlicht in:	Cancers 2021-01, Vol.13 (3), p.489
Hauptverfasser:	James, Claire D, Saini, Siddharth, Sesay, Fatmata, Ko, Kevin, Felthousen-Rusbasan, Jessica, Iness, Audra N, Nulton, Tara, Windle, Brad, Dozmorov, Mikhail G, Morgan, Iain M, Litovchick, Larisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell cycle Cell proliferation Cervical cancer Competition Dimerization E2F protein Gene expression Genomes Head & neck cancer Head and neck carcinoma Human papillomavirus Keratinocytes Kinases Papillomaviridae Proteins Retina Retinoblastoma Retinoblastoma protein Transcription Tumorigenesis Tumors
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