Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma
Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of and genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of and in a cohort of 82 adults with ACC and to establi...
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| Veröffentlicht in: | International journal of molecular sciences 2021-01, Vol.22 (3), p.1238 |
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| creator | Brondani, Vania Balderrama Lacombe, Amanda Meneses Ferreira Mariani, Beatriz Marinho de Paula Montenegro, Luciana Soares, Iberê Cauduro Bezerra-Neto, João Evangelista Tanno, Fabio Yoshiaki Srougi, Victor Chambo, José Luis Mendonca, Berenice Bilharinho Almeida, Madson Q Zerbini, Maria Claudia Nogueira Fragoso, Maria Candida Barisson Villares |
| description | Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of
and
genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of
and
in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of
and
was associated with a decrease in overall survival (OS) (
= 0.045,
= 0.012, respectively). The Cox regression for
protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997;
= 0.049) when compared with ≤1.5; for
expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852;
= 0.015) when compared with ≤2. High
and
protein expressions were associated with optimistic recurrence-free survival (RFS) (
= 0.027 and
= 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for
expression >2.7 (
= 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for
expression >2 (
= 0.013). In conclusion, low protein expression of
and
are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings. |
| doi_str_mv | 10.3390/ijms22031238 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7866180</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2484414963</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-be7eddaccd3f7f9edd09ec3b0696afeaa1f410d95f3ab77a1d3706794ef10b783</originalsourceid><addsrcrecordid>eNpdkcFrFDEUxoNYbK3ePEvAiwe3JpOZycxFWJZWhXWVUkG8hDeZl23WmWSbZFb73zdLa1m9JA_e7_t4Hx8hrzg7E6Jl7-1mjEXBBC9E84Sc8LIoZozV8unBfEyex7hhrBBF1T4jx0JUPGurE5KW_jf9FnxC6-j5n23AGK131Bva-XRN51eXPyi4nv5cXV4ICpGu_A4HusI1JLvDvXbtfExW0y8QfmGIe-28n4aU34DOax_yFga6gKCt8yO8IEcGhogvH_5T8v3i_Grxabb8-vHzYr6c6ZIXadahxL4HrXthpGnzzFrUomN1W4NBAG5Kzvq2MgI6KYH3QuawbYmGs0424pR8uPfdTt2IvUaXAgxqG-wI4VZ5sOrfjbPXau13SjZ1zRuWDd4-GAR_M2FMarRR4zCAQz9FVZSNaLiQlczom__QjZ-Cy_H2VFnysq1Fpt7dUzr4GAOax2M4U_s61WGdGX99GOAR_tufuAP5651a</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2484414963</pqid></control><display><type>article</type><title>Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Brondani, Vania Balderrama ; Lacombe, Amanda Meneses Ferreira ; Mariani, Beatriz Marinho de Paula ; Montenegro, Luciana ; Soares, Iberê Cauduro ; Bezerra-Neto, João Evangelista ; Tanno, Fabio Yoshiaki ; Srougi, Victor ; Chambo, José Luis ; Mendonca, Berenice Bilharinho ; Almeida, Madson Q ; Zerbini, Maria Claudia Nogueira ; Fragoso, Maria Candida Barisson Villares</creator><creatorcontrib>Brondani, Vania Balderrama ; Lacombe, Amanda Meneses Ferreira ; Mariani, Beatriz Marinho de Paula ; Montenegro, Luciana ; Soares, Iberê Cauduro ; Bezerra-Neto, João Evangelista ; Tanno, Fabio Yoshiaki ; Srougi, Victor ; Chambo, José Luis ; Mendonca, Berenice Bilharinho ; Almeida, Madson Q ; Zerbini, Maria Claudia Nogueira ; Fragoso, Maria Candida Barisson Villares</creatorcontrib><description>Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of
and
genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of
and
in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of
and
was associated with a decrease in overall survival (OS) (
= 0.045,
= 0.012, respectively). The Cox regression for
protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997;
= 0.049) when compared with ≤1.5; for
expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852;
= 0.015) when compared with ≤2. High
and
protein expressions were associated with optimistic recurrence-free survival (RFS) (
= 0.027 and
= 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for
expression >2.7 (
= 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for
expression >2 (
= 0.013). In conclusion, low protein expression of
and
are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22031238</identifier><identifier>PMID: 33513905</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescent ; Adrenal Cortex Neoplasms - metabolism ; Adrenal Cortex Neoplasms - mortality ; Adrenal Cortex Neoplasms - pathology ; Adrenocortical Carcinoma - metabolism ; Adrenocortical Carcinoma - mortality ; Adrenocortical Carcinoma - pathology ; Adult ; Age ; Aged ; Aged, 80 and over ; ATRX protein ; Biomarkers, Tumor - metabolism ; Cancer ; Cohort Studies ; Disease-Free Survival ; Female ; Gene expression ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Ki-67 Antigen - metabolism ; Male ; Malignancy ; Markers ; Medical prognosis ; Middle Aged ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Neuroendocrine tumors ; Pediatrics ; Prognosis ; Protein arrays ; Protein expression ; Proteins ; Regression Analysis ; Survival ; Tissue Array Analysis ; Tumorigenesis ; Tumors ; Ubiquitin-Protein Ligases - metabolism ; X-linked Nuclear Protein - metabolism</subject><ispartof>International journal of molecular sciences, 2021-01, Vol.22 (3), p.1238</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-be7eddaccd3f7f9edd09ec3b0696afeaa1f410d95f3ab77a1d3706794ef10b783</citedby><cites>FETCH-LOGICAL-c412t-be7eddaccd3f7f9edd09ec3b0696afeaa1f410d95f3ab77a1d3706794ef10b783</cites><orcidid>0000-0003-1762-1084 ; 0000-0002-7408-9816</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866180/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866180/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27913,27914,53780,53782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33513905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brondani, Vania Balderrama</creatorcontrib><creatorcontrib>Lacombe, Amanda Meneses Ferreira</creatorcontrib><creatorcontrib>Mariani, Beatriz Marinho de Paula</creatorcontrib><creatorcontrib>Montenegro, Luciana</creatorcontrib><creatorcontrib>Soares, Iberê Cauduro</creatorcontrib><creatorcontrib>Bezerra-Neto, João Evangelista</creatorcontrib><creatorcontrib>Tanno, Fabio Yoshiaki</creatorcontrib><creatorcontrib>Srougi, Victor</creatorcontrib><creatorcontrib>Chambo, José Luis</creatorcontrib><creatorcontrib>Mendonca, Berenice Bilharinho</creatorcontrib><creatorcontrib>Almeida, Madson Q</creatorcontrib><creatorcontrib>Zerbini, Maria Claudia Nogueira</creatorcontrib><creatorcontrib>Fragoso, Maria Candida Barisson Villares</creatorcontrib><title>Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of
and
genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of
and
in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of
and
was associated with a decrease in overall survival (OS) (
= 0.045,
= 0.012, respectively). The Cox regression for
protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997;
= 0.049) when compared with ≤1.5; for
expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852;
= 0.015) when compared with ≤2. High
and
protein expressions were associated with optimistic recurrence-free survival (RFS) (
= 0.027 and
= 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for
expression >2.7 (
= 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for
expression >2 (
= 0.013). In conclusion, low protein expression of
and
are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings.</description><subject>Adolescent</subject><subject>Adrenal Cortex Neoplasms - metabolism</subject><subject>Adrenal Cortex Neoplasms - mortality</subject><subject>Adrenal Cortex Neoplasms - pathology</subject><subject>Adrenocortical Carcinoma - metabolism</subject><subject>Adrenocortical Carcinoma - mortality</subject><subject>Adrenocortical Carcinoma - pathology</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>ATRX protein</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Malignancy</subject><subject>Markers</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neuroendocrine tumors</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Protein arrays</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Regression Analysis</subject><subject>Survival</subject><subject>Tissue Array Analysis</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><subject>X-linked Nuclear Protein - metabolism</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkcFrFDEUxoNYbK3ePEvAiwe3JpOZycxFWJZWhXWVUkG8hDeZl23WmWSbZFb73zdLa1m9JA_e7_t4Hx8hrzg7E6Jl7-1mjEXBBC9E84Sc8LIoZozV8unBfEyex7hhrBBF1T4jx0JUPGurE5KW_jf9FnxC6-j5n23AGK131Bva-XRN51eXPyi4nv5cXV4ICpGu_A4HusI1JLvDvXbtfExW0y8QfmGIe-28n4aU34DOax_yFga6gKCt8yO8IEcGhogvH_5T8v3i_Grxabb8-vHzYr6c6ZIXadahxL4HrXthpGnzzFrUomN1W4NBAG5Kzvq2MgI6KYH3QuawbYmGs0424pR8uPfdTt2IvUaXAgxqG-wI4VZ5sOrfjbPXau13SjZ1zRuWDd4-GAR_M2FMarRR4zCAQz9FVZSNaLiQlczom__QjZ-Cy_H2VFnysq1Fpt7dUzr4GAOax2M4U_s61WGdGX99GOAR_tufuAP5651a</recordid><startdate>20210127</startdate><enddate>20210127</enddate><creator>Brondani, Vania Balderrama</creator><creator>Lacombe, Amanda Meneses Ferreira</creator><creator>Mariani, Beatriz Marinho de Paula</creator><creator>Montenegro, Luciana</creator><creator>Soares, Iberê Cauduro</creator><creator>Bezerra-Neto, João Evangelista</creator><creator>Tanno, Fabio Yoshiaki</creator><creator>Srougi, Victor</creator><creator>Chambo, José Luis</creator><creator>Mendonca, Berenice Bilharinho</creator><creator>Almeida, Madson Q</creator><creator>Zerbini, Maria Claudia Nogueira</creator><creator>Fragoso, Maria Candida Barisson Villares</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1762-1084</orcidid><orcidid>https://orcid.org/0000-0002-7408-9816</orcidid></search><sort><creationdate>20210127</creationdate><title>Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma</title><author>Brondani, Vania Balderrama ; Lacombe, Amanda Meneses Ferreira ; Mariani, Beatriz Marinho de Paula ; Montenegro, Luciana ; Soares, Iberê Cauduro ; Bezerra-Neto, João Evangelista ; Tanno, Fabio Yoshiaki ; Srougi, Victor ; Chambo, José Luis ; Mendonca, Berenice Bilharinho ; Almeida, Madson Q ; Zerbini, Maria Claudia Nogueira ; Fragoso, Maria Candida Barisson Villares</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-be7eddaccd3f7f9edd09ec3b0696afeaa1f410d95f3ab77a1d3706794ef10b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Neoplasms - metabolism</topic><topic>Adrenal Cortex Neoplasms - mortality</topic><topic>Adrenal Cortex Neoplasms - pathology</topic><topic>Adrenocortical Carcinoma - metabolism</topic><topic>Adrenocortical Carcinoma - mortality</topic><topic>Adrenocortical Carcinoma - pathology</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>ATRX protein</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Malignancy</topic><topic>Markers</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neuroendocrine tumors</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Protein arrays</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Regression Analysis</topic><topic>Survival</topic><topic>Tissue Array Analysis</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Ubiquitin-Protein Ligases - metabolism</topic><topic>X-linked Nuclear Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brondani, Vania Balderrama</creatorcontrib><creatorcontrib>Lacombe, Amanda Meneses Ferreira</creatorcontrib><creatorcontrib>Mariani, Beatriz Marinho de Paula</creatorcontrib><creatorcontrib>Montenegro, Luciana</creatorcontrib><creatorcontrib>Soares, Iberê Cauduro</creatorcontrib><creatorcontrib>Bezerra-Neto, João Evangelista</creatorcontrib><creatorcontrib>Tanno, Fabio Yoshiaki</creatorcontrib><creatorcontrib>Srougi, Victor</creatorcontrib><creatorcontrib>Chambo, José Luis</creatorcontrib><creatorcontrib>Mendonca, Berenice Bilharinho</creatorcontrib><creatorcontrib>Almeida, Madson Q</creatorcontrib><creatorcontrib>Zerbini, Maria Claudia Nogueira</creatorcontrib><creatorcontrib>Fragoso, Maria Candida Barisson Villares</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brondani, Vania Balderrama</au><au>Lacombe, Amanda Meneses Ferreira</au><au>Mariani, Beatriz Marinho de Paula</au><au>Montenegro, Luciana</au><au>Soares, Iberê Cauduro</au><au>Bezerra-Neto, João Evangelista</au><au>Tanno, Fabio Yoshiaki</au><au>Srougi, Victor</au><au>Chambo, José Luis</au><au>Mendonca, Berenice Bilharinho</au><au>Almeida, Madson Q</au><au>Zerbini, Maria Claudia Nogueira</au><au>Fragoso, Maria Candida Barisson Villares</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-01-27</date><risdate>2021</risdate><volume>22</volume><issue>3</issue><spage>1238</spage><pages>1238-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of
and
genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of
and
in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of
and
was associated with a decrease in overall survival (OS) (
= 0.045,
= 0.012, respectively). The Cox regression for
protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273-0.997;
= 0.049) when compared with ≤1.5; for
expression >2, the HR for OS was 0.441 (95% CI, 0.229-0.852;
= 0.015) when compared with ≤2. High
and
protein expressions were associated with optimistic recurrence-free survival (RFS) (
= 0.027 and
= 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111-0.932) for
expression >2.7 (
= 0.037), and an HR of 0.333 (95%CI, 0.140-0.790) for
expression >2 (
= 0.013). In conclusion, low protein expression of
and
are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33513905</pmid><doi>10.3390/ijms22031238</doi><orcidid>https://orcid.org/0000-0003-1762-1084</orcidid><orcidid>https://orcid.org/0000-0002-7408-9816</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-01, Vol.22 (3), p.1238 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7866180 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adolescent Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - mortality Adrenal Cortex Neoplasms - pathology Adrenocortical Carcinoma - metabolism Adrenocortical Carcinoma - mortality Adrenocortical Carcinoma - pathology Adult Age Aged Aged, 80 and over ATRX protein Biomarkers, Tumor - metabolism Cancer Cohort Studies Disease-Free Survival Female Gene expression Humans Immunohistochemistry Kaplan-Meier Estimate Ki-67 Antigen - metabolism Male Malignancy Markers Medical prognosis Middle Aged Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neuroendocrine tumors Pediatrics Prognosis Protein arrays Protein expression Proteins Regression Analysis Survival Tissue Array Analysis Tumorigenesis Tumors Ubiquitin-Protein Ligases - metabolism X-linked Nuclear Protein - metabolism |
| title | Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A30%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20Protein%20Expression%20of%20both%20ATRX%20and%20ZNRF3%20as%20Novel%20Negative%20Prognostic%20Markers%20of%20Adult%20Adrenocortical%20Carcinoma&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Brondani,%20Vania%20Balderrama&rft.date=2021-01-27&rft.volume=22&rft.issue=3&rft.spage=1238&rft.pages=1238-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms22031238&rft_dat=%3Cproquest_pubme%3E2484414963%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2484414963&rft_id=info:pmid/33513905&rfr_iscdi=true |