Small Molecule-Based Prodrug Targeting Prostate Specific Membrane Antigen for the Treatment of Prostate Cancer

Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains a deadly disease. New targeted treatment options are urgently needed. PSMA is highly expressed in prostate cancer and has been an attractive biomarker for the treatment of prostate cancer....

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Veröffentlicht in:	Cancers 2021-01, Vol.13 (3), p.417
Hauptverfasser:	Wang, Xinning, Shirke, Aditi, Walker, Ethan, Sun, Rongcan, Ramamurthy, Gopolakrishnan, Wang, Jing, Shan, Lingpeng, Mangadlao, Joey, Dong, Zhipeng, Li, Jing, Wang, Ziying, Schluchter, Mark, Luo, Dong, Wang, Yu, Stauffer, Shaun, Brady-Kalnay, Susann, Hoimes, Christopher, Lee, Zhenghong, Basilion, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antibodies Antigens Antitumor activity Cancer therapies Castration Chemotherapy Cytotoxicity Drugs FDA approval Feasibility studies Ligands Metastases Metastasis Prostate cancer
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