Targeted Deletion of CXCR2 in Myeloid Cells Alters the Tumor Immune Environment to Improve Antitumor Immunity

Recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment (TME) contributes to cancer immune evasion. MDSCs express the chemokine receptor CXCR2, and inhibiting CXCR2 suppresses the recruitment of MDSCs into the tumor and the premetastatic niche. Here, we compared the gr...

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Veröffentlicht in:	Cancer immunology research 2021-02, Vol.9 (2), p.200-213
Hauptverfasser:	Yang, Jinming, Yan, Chi, Vilgelm, Anna E, Chen, Sheau-Chiann, Ayers, Gregory D, Johnson, Christopher A, Richmond, Ann
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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