Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to benefit recurrent glioblastoma (rGBM) treatment. This study is a dose-escalating pilot trial using a device combining ne...

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Veröffentlicht in:	Science advances 2021-02, Vol.7 (6)
Hauptverfasser:	Chen, Ko-Ting, Chai, Wen-Yen, Lin, Ya-Jui, Lin, Chia-Jung, Chen, Pin-Yuan, Tsai, Hong-Chieh, Huang, Chiung-Yin, Kuo, John S, Liu, Hao-Li, Wei, Kuo-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied Sciences and Engineering Blood-Brain Barrier Brain Brain Neoplasms - therapy Drug Delivery Systems - methods Glioblastoma Humans Immunization Immunology Magnetic Resonance Imaging Microbubbles Neuronavigation - methods Rats SciAdv r-articles Tumor Microenvironment
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