Uric acid released from poly(ε‐caprolactone) fibers as a treatment platform for spinal cord injury

Spinal cord injury (SCI) is characterized by a primary mechanical phase of injury, resulting in physical tissue damage, and a secondary pathological phase, characterized by biochemical processes contributing to inflammation, neuronal death, and axonal demyelination. Glutamate‐induced excitotoxicity...

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Veröffentlicht in:	Journal of tissue engineering and regenerative medicine 2021-01, Vol.15 (1), p.14-23
Hauptverfasser:	Singh, Nisha K., Khaliq, Salman, Patel, Mann, Wheeler, N'Dea, Vedula, Sudeepti, Freeman, Joseph W., Firestein, Bonnie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacokinetics Antioxidants - pharmacology Astrocytes Biocompatibility Biodegradability Biodegradation Cell culture Cell death Controlled release Damage Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Demyelination DNA damage Excitotoxicity Fibers Free radicals Glutamate receptors glutamate‐induced excitotoxicity Inflammation Mitochondria Neurogenesis neuroprotection Patients poly(ε‐caprolactone) fibers Polycaprolactone Polyesters - chemistry Polyesters - pharmacology Polyethylene glycol Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Regenerative medicine Spinal Cord - metabolism Spinal cord injuries Spinal Cord Injuries - metabolism Spinal Cord Injuries - therapy spinal cord organotypicculture Sustained release Synapses Therapeutic targets Tissue engineering Uric acid Uric Acid - chemistry Uric Acid - pharmacokinetics Uric Acid - pharmacology
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