Novel Short-Chain Quinones to Treat Vision Loss in a Rat Model of Diabetic Retinopathy

Diabetic retinopathy (DR), one of the leading causes of blindness, is mainly diagnosed based on the vascular pathology of the disease. Current treatment options largely focus on this aspect with mostly insufficient therapeutic long-term efficacy. Mounting evidence implicates mitochondrial dysfunctio...

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Veröffentlicht in:	International journal of molecular sciences 2021-01, Vol.22 (3), p.1016
Hauptverfasser:	Daniel, Abraham, Premilovac, Dino, Foa, Lisa, Feng, Zikai, Shah, Krupali, Zhang, Qianyi, Woolley, Krystel L, Bye, Nicole, Smith, Jason A, Gueven, Nuri
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Angiogenesis Animals Antioxidants - pharmacology Antioxidants - therapeutic use Blindness Chains Diabetes Diabetes mellitus (non-insulin dependent) Diabetic retinopathy Diabetic Retinopathy - drug therapy Drug development Etiology Eye Eye (anatomy) Gliosis Hyperglycemia Male Mitochondria Mitochondria - drug effects Mitochondrial DNA Normalizing Oligopeptides - pharmacology Oligopeptides - therapeutic use Optokinetic response Oxidative stress Pathology Quinones Rats Rats, Long-Evans Retina Retinopathy Rodents Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Ubiquinone - therapeutic use Vision Vision, Ocular Visual acuity Visual perception
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