Functions of Gle1 are governed by two distinct modes of self-association

Gle1 is a conserved, essential regulator of DEAD-box RNA helicases, with critical roles defined in mRNA export, translation initiation, translation termination, and stress granule formation. Mechanisms that specify which, where, and when DDXs are targeted by Gle1 are critical to understand. In addit...

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Veröffentlicht in:	The Journal of biological chemistry 2020-12, Vol.295 (49), p.16813-16825
Hauptverfasser:	Mason, Aaron C., Wente, Susan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Biology Chromatography, Gel DEAD-box protein Dynamic Light Scattering Gle1 HeLa Cells Humans Microscopy, Fluorescence mRNA mRNA export Mutagenesis nuclear pore Nucleocytoplasmic Transport Proteins - antagonists & inhibitors Nucleocytoplasmic Transport Proteins - genetics Nucleocytoplasmic Transport Proteins - metabolism oligomerization protein aggregation Protein Domains Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Multimerization Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism stress granules translation regulation
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