Elucidation of Epigenetic Landscape in Coronary Artery Disease: A Review on Basic Concept to Personalized Medicine
Despite extensive clinical research and management protocols applied in the field of coronary artery diseases (CAD), it still holds the number 1 position in mortality worldwide. This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets...
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| description | Despite extensive clinical research and management protocols applied in the field of coronary artery diseases (CAD), it still holds the number 1 position in mortality worldwide. This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets to improve the outcome of CAD. In precision medicine, epigenetic changes play a vital role in disease onset and progression. Epigenetics is the study of heritable changes that do not affect the alterations of DNA sequence in the genome. It comprises various covalent modifications that occur in DNA or histone proteins affecting the spatial arrangement of the DNA and histones. These multiple modifications include DNA/histone methylation, acetylation, phosphorylation, and SUMOylation. Besides these covalent modifications, non-coding RNAs—viz. miRNA, lncRNA, and circRNA are also involved in epigenetics. Smoking, alcohol, diet, environmental pollutants, obesity, and lifestyle are some of the prime factors affecting epigenetic alterations. Novel molecular techniques such as next-generation sequencing, chromatin immunoprecipitation, and mass spectrometry have been developed to identify important cross points in the epigenetic web in relation to various diseases. The studies regarding exploration of epigenetics, have led researchers to identify multiple diagnostic markers and therapeutic targets that are being used in different disease diagnosis and management. Here in this review, we will discuss various ground-breaking contributions of past and recent studies in the epigenetic field in concert with coronary artery diseases. Future prospects of epigenetics and its implication in CAD personalized medicine will also be discussed in brief. |
| doi_str_mv | 10.1177/2516865720988567 |
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This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets to improve the outcome of CAD. In precision medicine, epigenetic changes play a vital role in disease onset and progression. Epigenetics is the study of heritable changes that do not affect the alterations of DNA sequence in the genome. It comprises various covalent modifications that occur in DNA or histone proteins affecting the spatial arrangement of the DNA and histones. These multiple modifications include DNA/histone methylation, acetylation, phosphorylation, and SUMOylation. Besides these covalent modifications, non-coding RNAs—viz. miRNA, lncRNA, and circRNA are also involved in epigenetics. Smoking, alcohol, diet, environmental pollutants, obesity, and lifestyle are some of the prime factors affecting epigenetic alterations. Novel molecular techniques such as next-generation sequencing, chromatin immunoprecipitation, and mass spectrometry have been developed to identify important cross points in the epigenetic web in relation to various diseases. The studies regarding exploration of epigenetics, have led researchers to identify multiple diagnostic markers and therapeutic targets that are being used in different disease diagnosis and management. Here in this review, we will discuss various ground-breaking contributions of past and recent studies in the epigenetic field in concert with coronary artery diseases. Future prospects of epigenetics and its implication in CAD personalized medicine will also be discussed in brief.</description><identifier>ISSN: 2516-8657</identifier><identifier>EISSN: 2516-8657</identifier><identifier>DOI: 10.1177/2516865720988567</identifier><identifier>PMID: 33598635</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acetylation ; Cardiovascular disease ; Chromatin ; Coronary artery ; Coronary vessels ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Epigenetics ; Genomes ; Heart diseases ; Histones ; Immunoprecipitation ; Mass spectroscopy ; miRNA ; Next-generation sequencing ; Nucleotide sequence ; Phosphorylation ; Pollutants ; Precision medicine ; Review ; SUMO protein ; Therapeutic targets ; Vein & artery diseases</subject><ispartof>Epigenetics Insights, 2021-01, Vol.14, p.2516865720988567</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021.</rights><rights>The Author(s) 2021. 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This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets to improve the outcome of CAD. In precision medicine, epigenetic changes play a vital role in disease onset and progression. Epigenetics is the study of heritable changes that do not affect the alterations of DNA sequence in the genome. It comprises various covalent modifications that occur in DNA or histone proteins affecting the spatial arrangement of the DNA and histones. These multiple modifications include DNA/histone methylation, acetylation, phosphorylation, and SUMOylation. Besides these covalent modifications, non-coding RNAs—viz. miRNA, lncRNA, and circRNA are also involved in epigenetics. Smoking, alcohol, diet, environmental pollutants, obesity, and lifestyle are some of the prime factors affecting epigenetic alterations. Novel molecular techniques such as next-generation sequencing, chromatin immunoprecipitation, and mass spectrometry have been developed to identify important cross points in the epigenetic web in relation to various diseases. The studies regarding exploration of epigenetics, have led researchers to identify multiple diagnostic markers and therapeutic targets that are being used in different disease diagnosis and management. Here in this review, we will discuss various ground-breaking contributions of past and recent studies in the epigenetic field in concert with coronary artery diseases. Future prospects of epigenetics and its implication in CAD personalized medicine will also be discussed in brief.</description><subject>Acetylation</subject><subject>Cardiovascular disease</subject><subject>Chromatin</subject><subject>Coronary artery</subject><subject>Coronary vessels</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Epigenetics</subject><subject>Genomes</subject><subject>Heart diseases</subject><subject>Histones</subject><subject>Immunoprecipitation</subject><subject>Mass spectroscopy</subject><subject>miRNA</subject><subject>Next-generation sequencing</subject><subject>Nucleotide sequence</subject><subject>Phosphorylation</subject><subject>Pollutants</subject><subject>Precision medicine</subject><subject>Review</subject><subject>SUMO protein</subject><subject>Therapeutic targets</subject><subject>Vein & artery diseases</subject><issn>2516-8657</issn><issn>2516-8657</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UUtLAzEQDqKoqHdPEvC8mmSbx3oQaq0PqCii55BmZ2ukJmuyreivN6W-wdMMk-8xkw-hXUoOKJXykHEqlOCSkUopLuQK2lyMisVs9Ue_gXZSeiSEMMJ7ouTraKMseaVyu4nicDqzrjadCx6HBg9bNwEPnbN4ZHydrGkBO48HIQZv4ivuxw5yOXUJTIIj3Me3MHfwgjP_xKTMGwRvoe1wF_ANxJRpU_cGNb6C2lnnYRutNWaaYOejbqH7s-Hd4KIYXZ9fDvqjwvYE64qKgGVG8aomzPCGSMGFYlKJsSINpbxmXBJaNj1VGpDNuMcqRituFRAzrkpbbqHjpW47Gz9BbcF30Ux1G91TPkQH4_TvF-8e9CTMdfYoqZBZYP9DIIbnGaROP4ZZzOckzQSrCM3_STOKLFE2hpQiNF8OlOhFUPpvUJmy93OzL8JnLBlQLAHJTODb9V_BdyUimuM</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Sumi, Mamta P</creator><creator>Mahajan, Bhawna</creator><creator>Sattar, Real Sumayya Abdul</creator><creator>Nimisha</creator><creator>Apurva</creator><creator>Kumar, Arun</creator><creator>Sharma, Abhay Kumar</creator><creator>Ahmad, Ejaz</creator><creator>Ali, Asgar</creator><creator>Saluja, Sundeep Singh</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Elucidation of Epigenetic Landscape in Coronary Artery Disease: A Review on Basic Concept to Personalized Medicine</title><author>Sumi, Mamta P ; 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This indicates that we need to work on precision medicine to discover the diagnostic, therapeutic, and prognostic targets to improve the outcome of CAD. In precision medicine, epigenetic changes play a vital role in disease onset and progression. Epigenetics is the study of heritable changes that do not affect the alterations of DNA sequence in the genome. It comprises various covalent modifications that occur in DNA or histone proteins affecting the spatial arrangement of the DNA and histones. These multiple modifications include DNA/histone methylation, acetylation, phosphorylation, and SUMOylation. Besides these covalent modifications, non-coding RNAs—viz. miRNA, lncRNA, and circRNA are also involved in epigenetics. Smoking, alcohol, diet, environmental pollutants, obesity, and lifestyle are some of the prime factors affecting epigenetic alterations. Novel molecular techniques such as next-generation sequencing, chromatin immunoprecipitation, and mass spectrometry have been developed to identify important cross points in the epigenetic web in relation to various diseases. The studies regarding exploration of epigenetics, have led researchers to identify multiple diagnostic markers and therapeutic targets that are being used in different disease diagnosis and management. Here in this review, we will discuss various ground-breaking contributions of past and recent studies in the epigenetic field in concert with coronary artery diseases. Future prospects of epigenetics and its implication in CAD personalized medicine will also be discussed in brief.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33598635</pmid><doi>10.1177/2516865720988567</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylation Cardiovascular disease Chromatin Coronary artery Coronary vessels Deoxyribonucleic acid DNA DNA methylation Epigenetics Genomes Heart diseases Histones Immunoprecipitation Mass spectroscopy miRNA Next-generation sequencing Nucleotide sequence Phosphorylation Pollutants Precision medicine Review SUMO protein Therapeutic targets Vein & artery diseases |
| title | Elucidation of Epigenetic Landscape in Coronary Artery Disease: A Review on Basic Concept to Personalized Medicine |
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