Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab

CD38-targeted antibody, daratumumab, is approved for the treatment of multiple myeloma (MM). Phase 1/2 studies GEN501/SIRIUS revealed a novel immunomodulatory mechanism of action (MOA) of daratumumab that enhanced the immune response, reducing natural killer (NK) cells without affecting efficacy or...

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Veröffentlicht in:	Leukemia 2021-02, Vol.35 (2), p.573-584
Hauptverfasser:	Casneuf, Tineke, Adams, Homer C., van de Donk, Niels W.C.J., Abraham, Yann, Bald, Jaime, Vanhoof, Greet, Van der Borght, Koen, Smets, Tina, Foulk, Brad, Nielsen, Karl C., Rusbuldt, Joshua, Axel, Amy, Lysaght, Andrew, Ceulemans, Hugo, Stevenaert, Frederik, Usmani, Saad Z., Plesner, Torben, Avet-Loiseau, Herve, Nijhof, Inger, Mutis, Tuna, Schecter, Jordan M., Chiu, Christopher, Bahlis, Nizar J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 38 631/250 631/67/1059 96/31 96/47 Adaptive immunity Antibodies Antibodies, Monoclonal - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers - analysis Cancer Research CD27 antigen CD38 antigen CD4 antigen CD69 antigen CD8 antigen Cell activation Critical Care Medicine Cytometry Depth profiling Development and progression Dexamethasone Dexamethasone - administration & dosage Drug therapy Drug therapy, Combination Effector cells Health aspects Hematology Histocompatibility antigen HLA Humans Immune response Immune system Immunological memory Immunomodulation Immunoregulation Immunosuppressive agents Immunotherapy Intensive Internal Medicine Killer cells Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lenalidomide - administration & dosage Lymphocytes Lymphocytes T Medicine Medicine & Public Health Memory cells Methods Monoclonal antibodies Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - immunology Multiple Myeloma - pathology Natural killer cells Observations Oncology Patient outcomes Steroids T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Targeted cancer therapy
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